CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster.

Journal of Cell Science
Elena Domanitskaya, Trudi Schüpbach

Abstract

The Notch signaling pathway plays important roles in a variety of developmental events. The context-dependent activities of positive and negative modulators dramatically increase the diversity of cellular responses to Notch signaling. In a screen for mutations affecting the Drosophila melanogaster follicular epithelium, we isolated a mutation in CoREST that disrupts the Notch-dependent mitotic-to-endocycle switch of follicle cells at stage 6 of oogenesis. We show that Drosophila CoREST positively regulates Notch signaling, acting downstream of the proteolytic cleavage of Notch but upstream of Hindsight activity; the Hindsight gene is a Notch target that coordinates responses in the follicle cells. We show that CoREST genetically interacts with components of the Notch repressor complex, Hairless, C-terminal Binding Protein and Groucho. In addition, we demonstrate that levels of H3K27me3 and H4K16 acetylation are dramatically increased in CoREST mutant follicle cells. Our data indicate that CoREST acts as a positive modulator of the Notch pathway in the follicular epithelium as well as in wing tissue, and suggests a previously unidentified role for CoREST in the regulation of Notch signaling. Given its high degree of conservation...Continue Reading

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Citations

Dec 12, 2012·Development·Donald T Fox, Robert J Duronio
Jan 15, 2014·Differentiation; Research in Biological Diversity·Liang MingHoward D Lipshitz
Sep 12, 2012·Genesis : the Journal of Genetics and Development·Brenda J CurtisAndrew K Dingwall
May 13, 2014·Developmental Biology·Dongyu JiaWu-Min Deng
Jun 22, 2012·Genetics Research International·Jingxia Xu, Thomas Gridley
May 14, 2014·Molecular and Cellular Biology·Álvaro P BarriosMaría E Andrés
Jul 14, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Camillia M MonestimeHoward I Sirotkin
Nov 9, 2019·Nucleic Acids Research·Igor MačinkovićAlexander Brehm
Jul 13, 2014·Journal of Cell Science·Gengqiang XieWu-Min Deng

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