Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities

Journal of Ethnopharmacology
Qaiser JabeenAnwar H Gilani

Abstract

Coriander (Coriandrum sativum) is traditionally used for various gastrointestinal and cardiovascular disorders and this study was designed to rationalize its use in dyspepsia, abdominal colic, diarrhea, hypertension and as diuretic. Coriander crude extract (Cs.Cr) was evaluated through in vitro and in vivo techniques. Cs.Cr caused atropine sensitive stimulatory effect in isolated guinea-pig ileum (0.1-10 mg/ml). In rabbit jejunum preparations, Cs.Cr evoked a similar contractile response but in the presence of atropine, it exhibited relaxation against both spontaneous and high K(+) (80 mM)-induced contractions as well as shifted the Ca(2+) concentration-response curves to right, similar to that caused by verapamil. Cs.Cr (1-30 mg/ml) caused fall in arterial blood pressure of anesthetized animals, partially blocked by atropine. Cs.Cr produced vasodilatation against phenylephrine and K(+) (80 mM)-induced contractions in rabbit aorta and cardio-depressant effect in guinea-pig atria. Cs.Cr produced diuresis in rats at 1-10mg/kg. Bio-assay-directed fractionation revealed the separation of spasmogenic and spasmolytic components in the aqueous and organic fractions respectively. These results indicate that coriander fruit exhibits gut ...Continue Reading

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Citations

Oct 3, 2012·BMC Complementary and Alternative Medicine·Mueen Ahmad ChaudharyAnwarul-Hassan Gilani
Feb 3, 2016·Frontiers in Pharmacology·Sara S Al DisiAli H Eid
Oct 27, 2009·Journal of Ethnopharmacology·Haroon KhanInamullah Khan
Nov 30, 2014·Journal of Ethnopharmacology·Amber Hanif PallaAnwarul-Hassan Gilani
Mar 18, 2015·Fitoterapia·Bochra LaribiTaoufik Bettaieb
Jul 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Dipak K PatelA V Ramachandran
Jul 2, 2011·Journal of Ethnopharmacology·Abderrahmane AissaouiBadiâa Lyoussi
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Mar 1, 2018·Pharmaceutical Biology·Emily Guzman, Jeanmaire Molina
May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simona Codruta HeghesLorena Filip
Dec 5, 2019·Plant Biotechnology Journal·Xiaoming SongXiyin Wang
Mar 17, 2020·Zebrafish·Kamila Cagliari ZenkiCristiani Isabel Banderó Walker
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Dec 14, 2019·Dose-response : a Publication of International Hormesis Society·Hafiz Muhammad AsifAbdul Sattar Hashmi
Dec 28, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Mohammed Ajebli, Mohamed Eddouks
Nov 12, 2020·Natural Products and Bioprospecting·Tarawanti VermaNagendra Singh Chauhan

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