Corifollitropin alfa compared with follitropin beta in GnRH-antagonist ovarian stimulation protocols in an unselected population undergoing IVF/ICSI

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Charalampos SiristatidisNikolaos Papantoniou

Abstract

Recombinant DNA technologies have produced Corifollitropin alfa (CFa) used during IVF/ICSI in order to keep the circulating FSH levels above the threshold necessary to support multi-follicular growth for a week. In this prospective case-control study, we compared 70 participants treated with 150 μg CFa combined with 150 IU of follitropin beta (study group) with 70 subfertile participants with matching baseline characteristics, conforming with the same inclusion criteria and treated with an antagonist protocol using follitropin beta (control group). Live birth was the primary outcome, while secondary outcome measures were IVF/ICSI cycles characteristics, including adverse events and complications. Live birth was determined in reduced rates in the study compared to the control group, reaching statistical significance [6/70 versus 20/70, p = 0.002], as also in the respective number of clinical pregnancies [9/70 versus 23/70, p = 0.005], although the incidence of miscarriage was similar for both groups [6/70 versus 5/70, p > 0.99]. Most of the secondary parameters examined were similar between groups. Logistic regression revealed that protocol and AFC had a direct impact on live birth. Ovarian stimulation with CFa does not seem to ...Continue Reading

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F A FaresI Boime
May 21, 2010·Reproductive Biomedicine Online·UNKNOWN Corifollitropin alfa Ensure Study Group
Apr 21, 2011·Human Reproduction·A P FerrarettiUNKNOWN ESHRE working group on Poor Ovarian Response Definition
Jun 15, 2011·Reproductive Biomedicine Online·William L LedgerBernadette M J L Mannaerts
Aug 6, 2011·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Jamie D Croxtall, Kate McKeage
Jan 27, 2012·Fertility and Sterility·Mohamed Abdelfattah Mahmoud YoussefHesham Al-Inany
May 1, 2015·Journal of Assisted Reproduction and Genetics·Charalampos SiristatidisCharalampos Chrelias
May 15, 2016·Reproductive Biomedicine Online·Georg GriesingerBarbara J Stegmann

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Citations

Jun 7, 2020·Journal of Assisted Reproduction and Genetics·Charalampos SiristatidisTheodoros N Sergentanis

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