Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells

International Immunopharmacology
Roberto GambariChung-Hin Chui

Abstract

Corilagin (beta-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose), a gallotannin identified in several plants, including Phyllanthus urinaria, has been shown to exhibit versatile medicinal activities. As far as possible anti-inflammatory effects of corilagin, only few reports are available, and the potential use of corilagin as possible therapeutic molecule for cystic fibrosis has not been evaluated. In the present paper we report experiments aimed at determining the activity of corilagin on nuclear factor kappaB (NF-kappaB) binding to DNA target and on the expression of the major pro-inflammatory gene involved in cystic fibrosis, interleukin-8 (IL-8). Both IL-8 mRNA content and IL-8 protein secretion were analyzed in cystic fibrosis bronchial IB3-1 cells stimulated by tumor necrosis factor-alpha (TNF-alpha), one of the most potent pro-inflammatory agents. The data obtained demonstrate that corilagin binds to NF-kappaB, inhibits NF-kappaB/DNA interactions and affects IL-8 gene expression in TNF-alpha treated IB3-1 cells. In addition, corilagin inhibits TNF-alpha induced secretion of MCP-1 and RANTES, exhibiting low or no effect on the release of G-CSF, IL-6 and VEGF. Therefore, corilagin might be of interest for experimental ...Continue Reading

References

Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·T Z KhanD W Riches
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·T L BonfieldM Berger
Mar 12, 2002·Pediatric Pulmonology·E PuchelleD Gaillard
Nov 26, 2002·The Journal of Biological Chemistry·Monica BorgattiRoberto Gambari
Jan 24, 2004·The European Respiratory Journal·R C Boucher
Mar 19, 2004·Journal of Medicinal Chemistry·Thomas A HalgrenJay L Banks
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Michael DorwartPhilip Thomas
Jul 27, 2005·Phytochemical Analysis : PCA·Lih-Jeng Juang, Shuenn-Jyi Sheu
Oct 19, 2006·Biochemical and Biophysical Research Communications·Cristina CiganaPaola Melotti
Feb 13, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S KinoshitaY Aniya
Dec 15, 2007·BMJ : British Medical Journal·Jane C DaviesAndrew Bush
Dec 19, 2008·PloS One·Monica BorgattiRoberto Gambari
Mar 24, 2009·Paediatric Drugs·Kristie R RossMichael W Konstan
Apr 24, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Desmond Kwok Po HauDavid Wang Fun Fong
Aug 6, 2009·Journal of Ethnobiology and Ethnomedicine·Chandra Prakash Kala
Sep 2, 2009·International Immunopharmacology·Elena NicolisGiulio Cabrini
Oct 17, 2009·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Edith T ZemanickFrank J Accurso
Nov 3, 2009·Chemical & Pharmaceutical Bulletin·Hari Prasad DevkotaShoji Yahara
Apr 7, 2010·Expert Review of Neurotherapeutics·George P AtkinsonEtty Tika N Benveniste
Oct 12, 2010·Journal of Biomedicine & Biotechnology·Monica BorgattiClaudio Nastruzzi
Nov 3, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Desmond Kwok-Po HauDavid Wang-Fun Fong
Jun 11, 2011·American Journal of Respiratory Cell and Molecular Biology·Maria Cristina DechecchiGiulio Cabrini

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Citations

Jun 3, 2014·International Journal of Molecular Sciences·Zheng WangLi-Jun Ma
Jan 27, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rafael C DutraJoão B Calixto
Jan 8, 2014·Phytotherapy Research : PTR·Alessandra GuerriniMonica Borgatti
Sep 10, 2014·Journal of Peptide Science : an Official Publication of the European Peptide Society·Valentino BezzerriAlessandra Romanelli
Jan 23, 2015·Journal of Gastroenterology and Hepatology·Rui Dong, Shan Zheng
Aug 13, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ilaria LamprontiRoberto Gambari
Aug 5, 2015·Cytotechnology·Manish KumarSatwinderjeet Kaur
May 9, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·F CervellatiG Valacchi
May 21, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Xin MaoLan-Zhen Zhang
Mar 25, 2015·Oxidative Medicine and Cellular Longevity·Ximena M MuresanGiuseppe Valacchi
Jun 2, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Wen-Tao YangFeng Jin
Jul 28, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Bingjing ZhengZheng Xiang
Jun 21, 2018·Journal of Cellular and Molecular Medicine·Yinping TongGang Song
Oct 18, 2018·Frontiers in Pharmacology·Madamanchi Geethangili, Shih-Torng Ding
Jan 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Omolara F YakubuEmeka E J Iweala
May 14, 2019·Frontiers in Molecular Neuroscience·Lu-Jun LiLei Zhao
Apr 15, 2015·Molecular Diversity·Giovanni MarzaroAdriana Chilin
Aug 28, 2020·Frontiers in Immunology·Giulio CabriniRoberto Gambari
May 25, 2021·Frontiers in Cell and Developmental Biology·Claire DumortierDenise Al Alam

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