CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila

G3 : Genes - Genomes - Genetics
Nancy L TranStuart J Newfeld

Abstract

CORL proteins (known as SKOR in mice, Fussel in humans and fussel in Flybase) are a family of CNS specific proteins related to Sno/Ski oncogenes. Their developmental and adult roles are largely unknown. A Drosophila CORL (dCORL) reporter gene is expressed in all Drosophila insulin-like peptide 2 (dILP2) neurons of the pars intercerebralis (PI) of the larval and adult brain. The transcription factor Drifter is also expressed in the PI in a subset of dCORL and dILP2 expressing neurons and in several non-dILP2 neurons. dCORL mutant virgin adult brains are missing all dILP2 neurons that do not also express Drifter. This phenotype is also seen when expressing dCORL-RNAi in neurosecretory cells of the PI. dCORL mutant virgin adults of both sexes have a significantly shorter lifespan than their parental strain. This longevity defect is completely reversed by mating (lifespan increases over 50% for males and females). Analyses of dCORL mutant mated adult brains revealed a complete rescue of dILP2 neurons without Drifter. Taken together, the data suggest that dCORL participates in a neural network connecting the insulin signaling pathway, longevity and mating. The conserved sequence and CNS specificity of all CORL proteins imply that th...Continue Reading

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Citations

Sep 19, 2019·G3 : Genes - Genomes - Genetics·Michael J StinchfieldStuart J Newfeld
Mar 13, 2020·G3 : Genes - Genomes - Genetics·Agapi DimitriadouStuart J Newfeld

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Methods Mentioned

BETA
transgenic
dissection

Software Mentioned

GraphPad Prism
Drifter
ImageJ
Excel

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