CORM-2 inhibits intracerebral hemorrhage-mediated inflammation.

Neurological Research
Zhi-Ying ChenRan Meng

Abstract

Background and purpose: Low-dose of carbon monoxide delivered by CO-releasing molecule-2 (CORM-2) had been confirmed having anti-inflammatory efficacy in some inflammatory diseases. Herein, we assessed the usefulness of CORM-2 in correcting intracerebral hemorrhage (ICH)-mediated inflammation.Methods: Healthy male Sprague Dawley (SD) rats randomly entered into four groups: sham-ICH, ICH, ICH+CORM-2, and ICH+ inactive carbon monoxide releasing molecule 2 (iCORM-2). ICH was induced by 50 μl of autologous arterial blood injected in situ in the rat brain. Neuro-functions of the ICH rats were evaluated with Garcia 18 scores at the 6th, 24th , 48th hou, and the fifthh day post-ICH. And brain tissues surrounding the hematoma area were collected from all ICH rats and assayed with Western blot and immunofluoresence analysis.Results: Neuro-dysfunctions in ICH rats were very severe than those in ICH +CORM-2 rats. Compared to sham group, the levels of HO-1, IKKβ, NF-κB, and TNF-α in ICH group began to elevate at the 6th hour, and reached to peak at the 48th hour post-ICH, all p < 0.05. While in ICH +CORM-2 group, the expressions of IKKβ, NF-κB, and TNF-α were very weaker than that in ICH group at every time points mentioned above; however,...Continue Reading

References

Jan 15, 1993·Science·A VermaS H Snyder
Apr 25, 2000·Cerebrovascular Diseases·A ArboixC Targa
Jan 26, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A ArboixM Balcells
Jul 5, 2011·Acta Neurochirurgica. Supplement·Berk OrakciogluO W Sakowitz
Mar 1, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Stefan ChlopickiRoberto Motterlini
Mar 23, 2012·Immunological Reviews·Shao-Cong Sun
May 24, 2012·Journal of Biomedicine & Biotechnology·Mingchang LiRuth Thiex
Jan 22, 2013·Biochemical Pharmacology·Kelly VerhelstRudi Beyaert
Jan 31, 2013·Toxicology and Applied Pharmacology·Sun Young ParkYoungHee Kim
Nov 14, 2013·Clinical & Developmental Immunology·Roslyn A Taylor, Lauren H Sansing
Dec 3, 2013·Progress in Neurobiology·Yu ZhouQing-Wu Yang
Dec 18, 2013·The Journal of Clinical Investigation·Jing Xue, Aida Habtezion
Jan 1, 2014·EMBO Reports·Michael Hinz, Claus Scheidereit
Apr 17, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Meiyun WangJinyuan Zhou
Jul 21, 2015·Cell Reports·Jessica M PerezDerek W Abbott
Feb 15, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jinghua WuJing Xue
Oct 15, 2018·Neuroscience·Soledad Porte AlconMónica Lidia Kotler
Jul 22, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Xi GuoMeng Tian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.