Cornea in acromegalic patients as a possible target of growth hormone action.

Journal of Endocrinological Investigation
A CiresiC Giordano

Abstract

GH exerts its effects on many organs and the eye also seems to be a target site, although few authors have investigated the corneal thickness in patients with acromegaly. To perform a detailed ophthalmological evaluation in acromegalic patients, in relation to disease activity. Twenty-eight acromegalic patients (11 males, 17 females) and 22 voluntary healthy subjects underwent complete metabolic and ophthalmological evaluation, including retinal thickness (RT), central corneal thickness (CCT), and intraocular pressure values (IOP). Significantly greater CCT values were found in all acromegalic patients in comparison with controls (567 vs 528.5 μm; p<0.001), without concomitant greater corrected IOP. No difference was found for RT. Analyzing these data according to disease activity, uncontrolled patients showed greater CCT values (573.5 vs 559 μm; p=0.002) and corrected IOP (17.4 vs 16 mmHg; p=0.001) than the controlled ones. CCT also correlated with basal and nadir GH after oral glucose load levels, IGF-I levels, and duration of active disease. Acromegaly is characterized by greater CCT values, supporting the hypothesis that GH excess may have stimulatory effects on the cornea as well as on other target organs. Higher GH levels...Continue Reading

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Citations

May 13, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Luciano QuarantaAnastasios G P Konstas
May 14, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Emine SenSerdar Guler
Jul 16, 2014·Archives of Gynecology and Obstetrics·Ayse Gul KebapcilarCetin Celik
Oct 14, 2014·Current Eye Research·Ceyhun AriciPinar Kadioglu
Jan 13, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Murat Atmacaİsmet Seven
Feb 18, 2017·Scientific Reports·Tina B McKayDimitrios Karamichos
Sep 2, 2014·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Esra HatipogluSadi Gundogdu
Feb 4, 2014·The British Journal of Ophthalmology·Ahmet OzkokPinar Kadioglu
Nov 19, 2013·European Journal of Ophthalmology·Pinar Nalcacioglu-YüksekkayaZehra Aycan

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