PMID: 7987Mar 1, 1976

Corneal and lens deposits due to treatment by phenothiazine type neuroleptics

Annales médico-psychologiques
R PougetJ Boulet


The authors have studied the corneal and lens lesions which appeared following a prolonged treatment by phenothiazines. They examined 186 patients: 147 took phenothiazines of which 35 of them presented anterior segment alterations. It seems that all phenothiazines can be held responsible for the apparition of these lesions. At this point the authors evaluated the global dose of the various phenothiazines which were administered. The threshold at which the association of these lesions seem to appear, seems to be situated around 300 gr. The total quantity of phenothiazines which are absorbed seems to be a good measure of the risk of ocular toxicity. In the case of one patient they observed that his visual keenness was lowered due to the importance of his corneal and lens lesions.

Related Concepts

Corneal Diseases
Dose-Response Relationship, Drug
Schamberg Disease
Antipsychotic Effect

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