Corneal asymmetry analysis by pentacam scheimpflug tomography for keratoconus diagnosis

Journal of Refractive Surgery
Jonatán David GallettiJeremías Gastón Galletti

Abstract

To evaluate intereye corneal asymmetry in Pentacam (Oculus Optikgeräte GmbH, Wetzlar, Germany) indices as a diagnostic method between normal patients and patients with keratoconus. A retrospective, observational case series of 177 healthy, 44 indeterminate, and 121 patients with keratoconus classified by Pentacam ectasia detection indices, randomized to analysis and validation datasets. Intereye asymmetry in 20 Scheimpflug tomography corneal descriptors was calculated and compared to develop diagnostic models. Intereye asymmetry was not correlated with anisometropia in healthy controls but was correlated with the ectasia grade of the worse eye in patients with keratoconus. Patients with keratoconus had significantly greater intereye asymmetry in all descriptors except for relational thickness indices. Intereye asymmetry in front elevation at the thinnest corneal location afforded the single highest diagnostic performance (71% sensitivity and 85% specificity), whereas the best multivariate model combining intereye asymmetry in anterior and posterior keratometry, corneal thickness, and front and back elevation at the thinnest point provided 65% sensitivity and 97% specificity. Multivariate models upheld their performance in the v...Continue Reading

References

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Citations

Jan 19, 2016·Zeitschrift für medizinische Physik·Bernardo T LopesRenato Ambrósio
May 1, 2016·American Journal of Ophthalmology·Giuliano de Oliveira FreitasMilton Ruiz Alve
Apr 23, 2017·The British Journal of Ophthalmology·Mohammad NaderanParviz Zarrinbakhsh
Jun 17, 2020·Cornea·Marta Jiménez-GarcíaUNKNOWN and The REDCAKE Study Group

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