Corneal collagen cross-linking: ectasia and beyond

Current Opinion in Ophthalmology
Kunal SuriParveen K Nagra

Abstract

Corneal collagen cross-linking has recently emerged as a novel approach for management of ectasia. This article reviews the literature published in the past 3 years about the expanding spectrum of cross-linking as a therapeutic modality and its complications. Recent studies have confirmed the beneficial effects of cross-linking in stabilization and to a lesser extent, regression of keratoconus and postrefractive surgery ectasia. Other applications include cross-linking as a combined procedure with intracorneal ring segments, and photorefractive keratectomy for ectasia, corneal edema, and infectious keratitis. Animal studies of chemical cross-linking of sclera as a potential treatment for progressive myopia have also been performed. Various modifications of the technique to increase the safety profile of cross-linking have been reported, including the use of hypoosmolar riboflavin, transepithelial cross-linking, customized epithelial debridement, and higher fluence shorter duration ultraviolet A light exposure. Reported complications include keratitis, corneal haze, endothelial cell loss and failure of treatment. Cross-linking has been shown to be an effective modality for corneal ectasia, the regression being less in patients w...Continue Reading

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Citations

Jan 31, 2013·Investigative Ophthalmology & Visual Science·Giuliano ScarcelliSeok Hyun Yun
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