Corneal crosslinking without epithelial removal

Journal of Cataract and Refractive Surgery
R Doyle StultingRoy S Rubinfeld

Abstract

To evaluate the effect of riboflavin-ultraviolet (UV)-A corneal crosslinking (CXL) without epithelial removal on ectatic corneal disease. Woolfson Eye Institute, Atlanta, Georgia, USA. Prospective observational study. Patients were treated with a new riboflavin formulation without epithelial removal, then exposed to UV light (365 nm) at 4 mW/cm2 with on-off cycling for 30 minutes. Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, maximum corneal curvature (maximum keratometry [Kmax]), total higher-order aberrations (HOAs), and coma were measured at 3, 6, 12, and 24 months postoperatively. Progression was defined as an increase of more than 1 diopter (D) in Kmax and loss of more than 1 line of CDVA. Five hundred twelve eyes of 308 patients with keratoconus or forme fruste keratoconus and 80 eyes of 55 patients with ectasia after laser in situ keratomileusis (LASIK) were treated with the new riboflavin formulation without epithelial removal; 229 patients received bilateral treatments, 95 of which were simultaneous. The mean UDVA and CDVA improved by 1 to 1.5 Snellen lines at 1 and 2 years postoperatively (P < .0001). Mean Kmax decreased by 0.48 D at 2 years postoperatively (P = .0002). Mean total HOAs and coma dec...Continue Reading

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Citations

Aug 27, 2019·Seminars in Ophthalmology·J J Yong, K M Hatch
Nov 11, 2019·Journal of Cataract and Refractive Surgery·Kenneth A BeckmanUNKNOWN ASCRS Cornea Clinical Committee
Apr 6, 2019·Journal of Cataract and Refractive Surgery·Roy S RubinfeldCarmine Ostacolo
Apr 6, 2019·Journal of Cataract and Refractive Surgery·Hidenaga Kobashi
May 31, 2019·Journal of Cataract and Refractive Surgery·Theo SeilerFarhad Hafezi
Jun 6, 2020·European Journal of Ophthalmology·Ahmed ElmassryKarim Gaballah
Dec 17, 2020·Asia-Pacific Journal of Ophthalmology·Colin Chan
Mar 6, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Andrea Conde PenedoFrancisco J Otero Espinar
Apr 21, 2021·International Ophthalmology·Emre Aydın, Mehmet Gökhan Aslan
May 19, 2021·Translational Vision Science & Technology·Evan K DackowskiRoy S Chuck
May 27, 2021·Journal of Refractive Surgery·Michael MimouniNeera Singal
Sep 18, 2021·Acta Ophthalmologica·Jurriaan BrekelmansRudy M M A Nuijts
Sep 26, 2020·Journal français d'ophtalmologie·S SaadN Bouheraoua

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