PMID: 7015217Feb 1, 1981Paper

Corneal donor material selection

Ophthalmology
M D WagonerM O'Neill-Dryja

Abstract

The authors conducted the first long-range study to demonstrate possible negative effects on the recipients of corneal transplantation from donors who had died of a systemic malignancy or of chronic neurologic disease. The results are reported of a long-term retrospective analysis of 73 patients who received 86 grafts from donors with various systemic malignancies. These patients were followed for a mean of 127 months. There was no evidence of the transfer of the same malignancy to any of the recipients. There was no increased incidence of malignancy or earlier mortality in our patient population when compared with a reference population. Graft infection, endophthalmitis, or local tumor growth was not observed. The authors state that at the present time there is no basis for excluding donors dying of systemic malignancy as a source of material for use in keratoplasty. The authors examined the case histories of six patients who received grafts from donors who had died of a neurological disease with a suspected viral etiology. In a follow-up period ranging from 120 to 174 months, no evidence of neurologic disease developed in any of the patients. The sample was too small to provide data necessary for drawing conclusions concernin...Continue Reading

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Citations

Apr 19, 2007·Cell and Tissue Banking·Manish J Gandhi, D Michael Strong
Oct 6, 2001·Cornea·N SalameB Delbosc
May 24, 2007·Transplantation·Antonio López-NavidadOscar Gris
Sep 3, 2009·Cornea·Joel SugarUNKNOWN Group Cornea Donor Study Investigator Group
Nov 11, 2008·Eye & Contact Lens·Xiaoming YaoYu-Guang He
Jun 15, 2019·QJM : Monthly Journal of the Association of Physicians·T SinghJ Chander
Jun 11, 2020·Case Reports in Ophthalmology·Matias IglickiHermino Pablo Negri

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