Corneal endothelial deposits in patients with cytomegalovirus retinitis

American Journal of Ophthalmology
K A WalterF Edelhauser H

Abstract

We studied six patients with human immunodeficiency virus (HIV) who had cytomegalovirus retinitis and abnormal endothelial deposits in at least one eye, to characterize their corneal endothelial deposits. The corneas of the six patients were examined by slit-lamp biomicroscopy and specular microscopy with morphometric analysis. The eyes of one patient with endothelial changes were obtained post mortem for histopathologic and ultrastructural examination. There were multiple diffuse, fine refractile, stellate-shaped deposits on the corneal endothelium in all affected eyes. The deposits were best seen with retroillumination. Two of six patients examined with specular microscopy showed severe abnormalities, which included marked areas of polymegathism and decreased endothelial cell counts. Examination of one eye obtained post mortem disclosed chains of dendritic macrophages and fibrin adherent to the apical surface of the corneal endothelium. There was no evidence of direct infection of the corneal endothelium by cytomegalovirus. Deposits on the corneal endothelium in patients with cytomegalovirus retinitis most likely result from an anterior uveitis. A preponderance of macrophages observed by histopathologic examination may be rel...Continue Reading

References

Jan 1, 1988·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·B Daicker
Aug 1, 1988·Australian and New Zealand Journal of Ophthalmology·A M BrooksW E Gillies
Jul 15, 1984·American Journal of Ophthalmology·M MatsudaR Manabe
May 1, 1980·Archives of Ophthalmology·G O WaringL S Rosenblatt

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Citations

Sep 27, 2006·Optometry : Journal of the American Optometric Association·Stephen P Boyer, Dax A Gay
Jul 12, 2017·Ocular Immunology and Inflammation·Jay SiakSoon-Phaik Chee
Aug 11, 2010·Cornea·Beatrice Bourghardt PeeboNeil Lagali
Apr 5, 2005·Ocular Immunology and Inflammation·Jennifer E ThorneDouglas A Jabs
Jan 8, 2020·Microorganisms·Monique MunroAnn-Marie Lobo-Chan
Apr 8, 2021·Ocular Immunology and Inflammation·Nicole Shu-Wen Chan, Soon-Phaik Chee
Jun 19, 2007·Survey of Ophthalmology·Bennie H JengDavid M Meisler

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