Corneal epithelial dendritic cells in patients with multiple sclerosis: An in vivo confocal microscopy study

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Valeria TestaMichele Iester

Abstract

To evaluate density and morphology of corneal epithelial dendritic cells (DCs) in patients with multiple sclerosis (MS) using in vivo confocal microscopy (IVCM). This was a single-center cross-sectional comparative study. All MS patients were clinically scored using the Expanded Disability Status Scale (EDSS) score. Patients underwent ophthalmological examination and then cornea was analyzed by IVCM Heidelberg Retina Tomograph (HRT 3) in combination with Rostock Cornea Module and CCD camera. Five sectors (central, nasal, temporal, inferior, superior and central area) were analyzed in both patient eyes, then for each sector one image was selected and analyzed by using the manual cell counting system offered with the software and ImageJ program. DCs density (cell/mm2) and DCs size (µm2) were considered for the analyses. Difference between the two groups and correlation between DCs, MS type, EDSS score, optic neuritis and ongoing therapy were analyzed. We enrolled 46 consecutive patients: 23 with MS (age 47.87 ± 7.22 years (mean ± standard deviation) and 21 healthy subjects (age 46.0 ± 12.6 years) from July 2017 to July 2018. MS patients showed a lower DCs density when compared with healthy subjects (p < 0.05). Moreover, we found ...Continue Reading

References

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Citations

Jan 25, 2021·Experimental Eye Research·Ruchi ShahAlexander V Ljubimov
Jul 10, 2021·Clinical & Experimental Ophthalmology·Holly R ChinneryLaura E Downie

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