PMID: 6403411Jan 1, 1983Paper

Corneal epithelial dysplasia after trifluridine use

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
P C MaudgalL Missotten

Abstract

Prolonged topical trifluridine treatment of herpes simplex keratitis in three elderly patients produced slightly raised dysplastic corneal epithelial lesions. The involved epithelium had a ground-glass appearance and exhibited opaque cells, edema, and spindle-shaped surface cells. Histopathology demonstrated severe cellular atypism, loss of cell polarity, dyskeratosis, parakeratosis, and a few mitotic figures. The pathological change was apparently intraepithelial. After scraping, the edema and opaque cells in the regenerated epithelium gradually disappeared in 3-4 months on cessation of trifluridine therapy. In one patient recurrence of dendritic keratitis, 5 weeks after scraping, was treated by topical bromovinyldeoxyuridine eye drops. Since severe epithelial dysplasia may represent a precancerous condition, prolonged use of trifluridine should be avoided.

References

Jun 1, 1979·The British Journal of Ophthalmology·D J CosterJ I McGill
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E De ClercqR T Walker
Feb 8, 1979·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·P C Maudgal, L Missotten
Nov 1, 1977·Archives of Ophthalmology·C S Foster, D Pavan-Langston
Dec 1, 1977·American Journal of Ophthalmology·D Pavan-Langston, C S Foster
Feb 9, 1978·Nature·A V CarranoJ L Minkler
Jan 1, 1978·The British Journal of Ophthalmology·P C Maudgal, L Missotten
Jan 1, 1978·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·P C Maudgal, L Missotten
Aug 1, 1978·Documenta Ophthalmologica. Advances in Ophthalmology·P C Maudgal
Jul 1, 1977·American Journal of Ophthalmology·L Missotten, P C Maudgal
Jan 1, 1975·Archives of Ophthalmology·M ItoiA R Gasset
Jul 1, 1967·Toxicology and Applied Pharmacology·G Kury, R J Crosby
May 1, 1980·The Journal of Infectious Diseases·E De ClercqD Shugar
Jan 1, 1980·The British Journal of Ophthalmology·O P Van Bijsterveld, H Post
Sep 26, 1981·British Medical Journal·J J CassimanH Van den Berghe
Aug 1, 1982·Archives of Ophthalmology·P C MaudgalL Missotten
Jan 1, 1981·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·P C MaudgalE De Meuter
Dec 1, 1981·Ophthalmology·R J Campbell, W M Bourne
Jan 1, 1980·Antimicrobial Agents and Chemotherapy·P C MaudgalA S Jones
Nov 1, 1980·British Medical Journal·E de ClercqP de Somer

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Citations

Mar 15, 1985·American Journal of Ophthalmology·I J Udell
May 1, 1995·Survey of Ophthalmology·G A Lee, L W Hirst
Jan 1, 2012·Ophthalmology and Eye Diseases·Afsun Sahin, Pedram Hamrah
Feb 16, 2018·Science Translational Medicine·Dinesh JaishankarDeepak Shukla
Dec 12, 2012·International Ophthalmology Clinics·Neha Gadaria-RathodPenny A Asbell
Jan 18, 2020·The British Journal of Ophthalmology·Rami DarwichIvan V Litvinov
Oct 18, 2018·Cellular and Molecular Life Sciences : CMLS·Lulia KoujahDeepak Shukla
Aug 1, 2020·Cornea·James Chodosh, Lawson Ung

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