Corneal fluorescein staining and ocular symptoms but not Schirmer test are useful as indicators of response to treatment in chronic ocular GVHD

The Ocular Surface
Francisco AmparoReza Dana

Abstract

To evaluate long-term ocular surface clinical signs and symptoms response to therapy in patients with chronic ocular GVHD. Retrospective review and data modeling. We reviewed the records of post-bone marrow transplantation patients who were newly diagnosed with ocular GVHD and initiated therapy, and analyzed changes in symptoms (Ocular Surface Disease Index [OSDI]; Symptom Assessment in Dry Eye [SANDE]) and signs (corneal fluorescein staining [CFS]; Schirmer test). We used a LOESS technique to fit a model in function of data variations and obtain a predictive value of the scores progression over time. The records of 123 patients who were followed-up for over 2 years (up to 62 months) were reviewed. The median baseline scores recorded were: OSDI 52 units, SANDE 62.2 units, CFS 2.0 Oxford units, and Schirmer 4 mm. After six months of follow up, scores improved for OSDI (-18.6 units, p = 0.007), SANDE (23.7 units, p = 0.01), and CFS (-0.7 Oxford units, p < 0.001). Data analysis showed that after a 2-year follow up the three parameters continued to improve: OSDI -13.67 units (27% reduction), SANDE -17.55 units (28%), CFS -1.1 units (54%), but Schirmer test scores progressively worsened -1.2 mm (22%). In patients with ocular GVHD sy...Continue Reading

Citations

Sep 1, 2020·Expert Review of Hematology·Marcell CsanádiJonas Mattsson
Oct 24, 2020·Current Eye Research·Golshan LatifiAhmad Kheirkhah
May 5, 2021·Transplantation and Cellular Therapy·Zhonghui K LuoVincent T Ho
Sep 21, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Jelena Marie KezicMariapia Degli-Esposti
Jul 7, 2021·Ocular Immunology and Inflammation·Jimena Tatiana Carreno-GaleanoReza Dana

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