Corneal In Vivo Laser-Scanning Confocal Microscopy Findings in Dry Eye Patients with Sjögren's Syndrome

Diagnostics
Yukihiro MatsumotoKazuo Tsubota

Abstract

To evaluate the changes in cornea in Sjögren's syndrome (SS) with a novel confocal microscopy device. Twenty-three right eyes of patients with SS (23 women; mean age, 65.4 ± 11.4 years) and 13 right eyes of 13 age- and sex-matched control subjects (13 women; mean age, 68.8 ± 9.8 years) were studied. Furthermore, eight right eyes of patients with SS (8 women; mean age, 66.9 ± 9.6 years) were studied to evaluate the corneal microscopic alterations after the treatment with topical 3% diquafosol sodium eye drops. All cases had tear quantity, tear breakup time (BUT), ocular surface staining measurements, and corneal in vivo laser-scanning confocal microscopy examinations. The density and area of corneal epithelial cells (superficial, wing, and basal), density of corneal stromal cells (anterior, intermediate, and posterior), density and area of corneal endothelial cells, density and morphology of corneal sub-basal nerve plexus, density of corneal sub-basal inflammatory cells were also assessed. The tear quantity, stability, and vital staining scores were significantly worse in patients with SS than in control subjects (p < 0.0001). Corneal superficial epithelial cell density was significantly lower in SS compared with control subject...Continue Reading

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Citations

Dec 2, 2020·Journal of Clinical Medicine·Gysbert-Botho van SettenWolfgang G K Müller-Lierheim
Apr 4, 2021·Genes·Anna Maria RoszkowskaPasquale Aragona
Mar 27, 2021·Clinical & Experimental Ophthalmology·Jodi HwangAnat Galor

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

Cell Count
GraphPad
Instat
Image J

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