Corneal involvement in systemic inflammatory diseases

Eye & Contact Lens
Beatriz A F GomesNewton Kara-Junior

Abstract

Corneal involvement in patients with systemic inflammatory disorders may be sight threatening, and it may be associated with a life-threatening disease. Significant systemic inflammatory diseases in this context are autoimmune connective tissue diseases, systemic autoimmune dermatological disorders, and autoimmune diseases of the lacrimal system. Keratoconjunctivitis sicca is usually the most common ocular finding in these patients. Peripheral ulcerative keratitis is a rare condition usually associated with increased ocular morbidity and also mortality, as it might act as an indicator of a more widespread vasculitis. Corneal biomechanical properties may also be altered in connective tissue diseases. Although recent studies suggest that the risk for corneal complications after ocular surgery in patients with quiescent autoimmune disease is minimal, caution is still recommended, as the knowledge about the corneal wound-healing process and the corneal biomechanical properties in these patients is not yet fully understood. This article reviews corneal abnormalities and characteristics in the setting of systemic inflammatory diseases.

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Citations

Aug 15, 2019·Ocular Immunology and Inflammation·Jung Lo, Linda Yi-Chieh Poon
Oct 28, 2019·Seminars in Ophthalmology·Levente CzompaAdam Kemeny-Beke
Aug 9, 2017·Case Reports in Ophthalmological Medicine·Pedro CoelhoElena Seara
Jan 25, 2021·Experimental Eye Research·Ruchi ShahAlexander V Ljubimov
Jan 26, 2021·Experimental Eye Research·Beatriz Fiuza Gomes, Marcony R Santhiago
May 29, 2021·Scientific Reports·Eszter SzalaiAdam Kemeny-Beke
Jul 13, 2021·PloS One·Vannarut SatitpitakulThanachaporn Kittipibul
Aug 20, 2021·Clinical Ophthalmology·Mohamed Salah El-Din MahmoudMohamed Farouk Abdelkader

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