PMID: 9432236Feb 12, 1998Paper

Corneal Langerhans cells. Behavior during storage in organ culture

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
N ArdjomandM E Reich

Abstract

Corneal HLA-DR antigens are going to be lost during organ culture storage. This study investigated if this phenomenon is based on down-regulation of the HLA-DR antigen, or on a loss of the HLA-DR-positive corneal Langerhans cells (LCs). Corneal LCs were stained in situ by the method of fluorescence-associated immunohistochemistry, and the organ culture mediums underwent flow cytometric analysis for HLA-DR-positive corneal LC at the end of the storage period. All stored corneas were negative for HLA-DR after 14 days and HLA-DR antigens could be detected in culture medium at the end of the storage time. Flow cytometry showed that organ culture storage leads to loss of HLA-DR-positive cells and not only to a loss of antigen presentation.

Citations

Sep 6, 2000·Transplantation·H J Völker-DiebenJ D'Amaro
Feb 9, 2010·Current Eye Research·Ulrike M IrschickEveline U Irschick
Aug 24, 2004·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·S KnappeR F Guthoff
Dec 7, 2007·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Selim DoganayHakan Demirtas

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