Corneal limbal stem cell deficiency associated with the anticancer drug S-1

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Kyeong Hwan Kim, Wan Soo Kim

Abstract

An oral antineoplastic drug, S-1, is known to be more effective with less toxicity and fewer gastrointestinal side effects than the conventional intravenous 5-fluorouracil. We report a case of limbal stem cell deficiency that occurred in a patient receiving chemotherapy using S-1 alone for gastric cancer. A 65-year-old woman with symptoms of grittiness and epiphora in both eyes for several months was referred to the ophthalmology clinic. She had been receiving S-1 orally after total gastrectomy for advanced gastric cancer. Slit lamp examination revealed an irregular hazy corneal epithelium in both eyes that extended to the center of the cornea overlying the pupil and showed late staining with fluorescein dye. Palisades of Vogt at the superior limbus were absent in both eyes. Best-corrected distance vision was 20/50 in both eyes with all other structures of the anterior and posterior segment unremarkable including a patent lacrimal drainage system. There was no change in the corneal lesions of either eye despite 3 months of topical therapy. The lesions did resolve in 4 months after discontinuation of S-1 therapy owing to acute renal failure. Early detection of this adverse reaction before significant visual loss through regular ...Continue Reading

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Citations

Mar 10, 2016·Seminars in Ophthalmology·Haumith Khan-Farooqi, James Chodosh
Nov 12, 2016·American Journal of Ophthalmology·Swathi KalikiVirender S Sangwan
Apr 21, 2017·Current Opinion in Ophthalmology·Kyeong Hwan Kim, Shahzad I Mian
Jan 8, 2019·Cornea·Sophie X DengUNKNOWN and The International Limbal Stem Cell Deficiency Working Group
Sep 27, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Hyo Seok LeeKyung Chul Yoon
Feb 13, 2021·Genesis : the Journal of Genetics and Development·Mohd Tayyab Adil, Jonathan J Henry
Feb 12, 2021·Experimental Eye Research·Clémence BonnetSophie X Deng

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