Corneal neovascularization.

Experimental Eye Research
Matthew P Nicholas, Naveen Mysore

Abstract

The optical clarity of the cornea is essential for maintaining good visual acuity. Corneal neovascularization, which is a major cause of vision loss worldwide, leads to corneal opacification and often contributes to a cycle of chronic inflammation. While numerous factors prevent angiogenesis within the cornea, infection, inflammation, hypoxia, trauma, corneal degeneration, and corneal transplantation can all disrupt these homeostatic safeguards to promote neovascularization. Here, we summarize its etiopathogenesis and discuss the molecular biology of angiogenesis within the cornea. We then review the clinical assessment and diagnostic evaluation of corneal neovascularization. Finally, we describe current and emerging therapies.

References

Dec 1, 1991·Ophthalmology·E D DonnenfeldL P Goldberg
Dec 1, 1991·Archives of Ophthalmology·T J BergstromV M Elner
Aug 1, 1990·Ophthalmology·C S Foster, M Calonge
Mar 1, 1988·Mycopathologia·A FonsC Gimeno
Apr 15, 1986·American Journal of Ophthalmology·D J BrowningM Lugo
Jun 1, 1980·Archives of Ophthalmology·C A CooperI H Leopold
Feb 1, 1982·The Journal of Experimental Medicine·Y M Centifanto-FitzgeraldB Roizman
Sep 1, 1995·American Journal of Ophthalmology·K NishidaS Yamamoto
Jan 1, 1995·Current Eye Research·G C Boneham, H B Collin
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·A KaipainenK Alitalo
May 1, 1996·American Journal of Ophthalmology·W K Chan, B A Weissman
Feb 13, 2001·Cardiovascular Research·E M ConwayP Carmeliet
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M StraslyF Bussolino
Mar 15, 2001·Cornea·M SitA R Slomovic
Aug 28, 2001·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C CursiefenG O Naumann
Nov 24, 2001·FEBS Letters·T KatoD T Azar
May 27, 2003·Investigative Ophthalmology & Visual Science·Wolfram SchreiberWolfgang Behrens-Baumann
Nov 5, 2003·American Journal of Ophthalmology·Alison L WongBartly J Mondino
Mar 24, 2004·Investigative Ophthalmology & Visual Science·Claus CursiefenJ Wayne Streilein
Apr 2, 2004·The Journal of Clinical Investigation·Claus CursiefenJ Wayne Streilein
Jan 27, 2005·Experimental Eye Research·Branka SamolovAnders Kvanta
Jul 27, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Pierre-Yves RobertUwe Pleyer
Feb 7, 2006·American Journal of Ophthalmology·Kirk R Wilhelmus, Dan B Jones
Jul 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Claus CursiefenReza Dana
Oct 20, 2006·Nature·Balamurali K AmbatiJayakrishna Ambati
Jun 15, 2007·Archives of Ophthalmology·Lu ChenM Reza Dana
Jul 31, 2007·Experimental Eye Research·Philipp S MuetherAntonia M Joussen
Sep 6, 2007·International Ophthalmology·Samar A Al-Swailem

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Citations

Jun 23, 2021·Scientific Reports·Darren Shu Jeng TingHarminder S Dua
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ning LyuJianguo Sun
Sep 9, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jian PanZipei Jiang

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