Corneal nerve regeneration after herpes simplex keratitis: A longitudinal in vivo confocal microscopy study

The Ocular Surface
Hamid-Reza MoeinPedram Hamrah

Abstract

To evaluate the long-term alterations of corneal nerves in patients with herpes simplex virus (HSV) keratitis using in vivo confocal microscopy (IVCM). Prospective, longitudinal, cross sectional. This study included 16 patients with a history of HSV keratitis and 15 age-matched normal controls. Slit-scanning IVCM was performed in all subjects at baseline and then after a mean follow-up of 37.3 ± 1.7 months in the patient group. Corneal subbasal nerve density and corneal sensation were compared between groups at baseline and follow-up. At baseline, the mean subbasal nerve density was significantly lower in both affected eyes (1.4 ± 0.6 mm/mm2) and contralateral unaffected eyes (6.4 ± 0.7 mm/mm2) compared with the controls (14.1 ± 1.6 mm/mm2; all P < .001). At the end of follow-up, the mean nerve density in affected eyes increased to 2.8 ± 0.7 mm/mm2 (P = .006), with no significant change in contralateral unaffected eyes (6.5 ± 1.0 mm/mm2, P = .72). However, both eyes had lower nerve density than controls (all P < .001). Corneal sensation was significantly lower in affected eyes (2.6 ± 0.6 cm) than in the control group (6.0 ± 0.0, P < .001) and showed no significant change at the end of follow-up (2.5 ± 0.6 cm, P = .80). Corneal ...Continue Reading

References

Feb 1, 1988·Archives of Ophthalmology·W D MathersM A Lemp
Jan 1, 1996·International Ophthalmology Clinics·T LatvalaT Tervo
Jul 11, 1998·Experimental Eye Research·T U LinnaT M Tervo
Oct 31, 1998·Journal of Cataract and Refractive Surgery·M Kohlhaas
Feb 24, 2001·International Ophthalmology Clinics·E A Davis, C H Dohlman
Apr 17, 2003·Experimental Eye Research·Linda J MüllerTimo M T Tervo
Jul 25, 2003·Nature·R Jeroen PasterkampAlex L Kolodkin
Nov 25, 2003·Eye·S BoniniA Lambiase
Jun 5, 2004·Ophthalmology·Yukihiro MatsumotoKazuo Tsubota
Aug 27, 2005·Investigative Ophthalmology & Visual Science·Salomon EsquenaziNicolas G Bazan
Dec 27, 2005·American Journal of Ophthalmology·Jay C ErieWilliam M Bourne
Jul 25, 2008·The British Journal of Ophthalmology·J A O MoilanenT M T Tervo
Nov 7, 2008·European Journal of Ophthalmology·G MartoneG M Tosi
Nov 26, 2010·Seminars in Ophthalmology·Andrea CruzatPedram Hamrah
Aug 11, 2011·Japanese Journal of Ophthalmology·Daisuke NagasatoMurat Dogru
Dec 30, 2011·Investigative Ophthalmology & Visual Science·Abed NamavariSandeep Jain
May 1, 2012·Survey of Ophthalmology·Asim V Farooq, Deepak Shukla
Sep 5, 2012·Progress in Retinal and Eye Research·A M RoweR L Hendricks
Mar 5, 2013·Survey of Ophthalmology·Dipika V Patel, Charles N McGhee
Sep 10, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Yael HacohenMing J Lim
Oct 11, 2013·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·F SemeraroC Costagliola
Dec 4, 2013·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Stefano De CillàLuca Rossetti
Jan 28, 2014·Survey of Ophthalmology·Brittany Simmons ShaheenSandeep Jain
May 3, 2014·Journal of Virology·Hongmin YunRobert L Hendricks
Jun 8, 2014·Disease-a-month : DM·Geoffrey M HillSurendar Dwarakanathan
Jan 15, 2015·Investigative Ophthalmology & Visual Science·Ana J Chucair-ElliottDaniel J J Carr
Aug 1, 2015·Investigative Ophthalmology & Visual Science·Rodrigo T MüllerPedram Hamrah
Apr 14, 2016·Investigative Ophthalmology & Visual Science·Hongmin YunRobert L Hendricks
Apr 24, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael J Bradshaw, Arun Venkatesan

❮ Previous
Next ❯

Citations

Apr 27, 2018·Current Opinion in Ophthalmology·Mehdi Roozbahani, Kristin M Hammersmith
Sep 22, 2018·Journal of Cellular Physiology·Leonardo MastropasquaHarminder S Dua
Dec 14, 2019·Eye & Contact Lens·William W BinottiPedram Hamrah
Nov 28, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·S MertschG Geerling
Nov 8, 2019·Ocular Immunology and Inflammation·Rong-Mei PengJing Hong
Oct 1, 2019·Current Opinion in Ophthalmology·Gabriel S Valerio, Charles C Lin
Dec 12, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·E M Messmer
Jul 17, 2019·International Ophthalmology·Wael SolimanAshraf K Al-Hussaini
Nov 25, 2020·The British Journal of Ophthalmology·Chareenun ChirapapaisanPedram Hamrah
Apr 26, 2020·Ophthalmic Plastic and Reconstructive Surgery·Jane S KimIlya M Leyngold
Oct 13, 2020·Experimental Eye Research·Sneh PatelAnat Galor
Mar 11, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Sana ArshadNicole A Carnt
Aug 20, 2021·The Ocular Surface·Leyla Yavuz SaricayPedram Hamrah
Sep 2, 2021·Clinical Ophthalmology·Chareenun ChirapapaisanAnupong Veeraburinon
Dec 20, 2018··Rajesh SharmaSukriti Gautam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.