Corneal penetration of simultaneously applied topical levofloxacin, norfloxacin and lomefloxacin in human eyes

Acta Ophthalmologica Scandinavica
Masakazu YamadaMasataka Kawai

Abstract

This study was performed to assess the corneal penetration of three topically applied fluoroquinolones (levofloxacin, norfloxacin and lomefloxacin) in corneal buttons obtained from patients undergoing penetrating keratoplasty. Fourteen patients received three drops each of 0.5% levofloxacin, 0.3% norfloxacin and 0.3% lomefloxacin (the standard clinically available preparations) over a 30-min interval beginning 90 mins before their scheduled keratoplasty. Corneal samples obtained from excised buttons at the time of surgery were stored at - 80 degrees until analysis. The concentration of the administered fluoroquinolones was measured using high-performance liquid chromatography. The mean corneal concentration of levofloxacin (4.6 +/- 3.5 microg/g, mean +/- standard deviation) was significantly higher than that of lomefloxacin (2.7 +/- 1.8 microg/g, p = 0.0018) and norfloxacin (1.3 +/- 1.2 microg/g, p = 0.00012). Levofloxacin achieves a higher mean corneal concentration than norfloxacin and lomefloxacin in the human cornea.

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Citations

Nov 10, 2009·Clinical Ophthalmology·Koji SugiokaYoshikazu Shimomura
Feb 20, 2013·Expert Opinion on Drug Delivery·Pravin PawarDipak K Majumdar
Oct 15, 2008·Current Eye Research·Moshe SnirRuth Axer-Siegel
Mar 1, 2012·Asia-Pacific Journal of Ophthalmology·Kianti R DarusmanAri Estuningtyas
Apr 23, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ting YangBin Xu
Jun 15, 2007·Current Opinion in Ophthalmology
May 1, 2007·Current Therapeutic Research, Clinical and Experimental·Ramazan YağciAtilla Bozkurt

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