Corneal rings with gram-negative bacteria

Archives of Ophthalmology
B J MondinoS I Brown


Corneal rings have been described with corneal ulcerations caused by Gram-negative bacteria. Corneal rings were produced by intracorneal injections of viable Pseudomonas aeruginosa as well as heat-inactivated suspensions of Gram-negative bacteria (P aeruginosa and Escherichia coli) but not Gram-positive bacteria (Staphylococcus aureus) or Freund's adjuvant. It is suggested that endotoxin is the factor responsible for their production since purified endotoxin produced corneal rings after intracorneal injection. Histopathological examination of the areas corresponding to the corneal rings disclosed that the rings represented accumulations of polymorphonuclear leukocytes. Direct immunofluorescent studies of the corneal rings revealed staining for properdin and C3 complement but not for immunoglobulins. The present report suggests that endotoxin has the ability to stimulate the alternate pathway of complement through properdin activation with the production of chemotactic fragments that attract polymorphonuclear leukocytes into the cornea.


Mar 1, 1982·American Journal of Ophthalmology·J B BelmontD Dulay
Sep 1, 1985·The British Journal of Ophthalmology·D K SenU K Baveja
May 1, 1984·The British Journal of Ophthalmology·A K Gupta, G S Sarin
Nov 1, 1984·The British Journal of Ophthalmology·N H WelshS L Gaffin
Jul 1, 1997·The British Journal of Ophthalmology·A C IonidesP G Hykin
Aug 30, 2001·Survey of Ophthalmology·A Ramsay, S Lightman
May 30, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Michael J Giese, Barry A Weissman
Feb 5, 2002·Ophthalmology·Kevin R YuhanBrian S Boxer Wachler
Sep 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Y IjiriT Kambara
Jan 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M Salem, L Ismail
Mar 15, 2011·Survey of Ophthalmology·Neelakshi BhagatMarco Zarbin
Jul 1, 1986·Survey of Ophthalmology·J B RobinH E Kaufman
Apr 15, 2008·Journal of Pediatric Ophthalmology and Strabismus·Arifo O KhanMichael D Wagoner
Jul 16, 2003·Eye & Contact Lens·Marc W RobboyCarolyn M Kalsow
Jan 1, 1996·Journal of Cataract and Refractive Surgery·K D TeichmannI Badr
Nov 26, 2018·Journal of Cataract and Refractive Surgery·Javed Hussain FarooquiSuneeta Dubey
Jan 1, 1985·Current Eye Research·S A ElgebalyD L Kreutzer
Mar 27, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Isabel WeinsteinLoay Daas

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.