Corneal staining and cell shedding during the development of solution-induced corneal staining

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Doerte LuensmannDesmond Fonn

Abstract

This non-dispensing cross-over study was conducted to determine if lenses presoaked in Opti-Free RepleniSH (OFR) or ReNu MultiPlus (RMP) cause solution-induced corneal staining (SICS) and subsequent cell sloughing before the typical 2 h in vivo examination point. METHODS.: Study lenses (PureVision) were worn bilaterally by 13 participants for periods of 15, 30, 60, and 120 min using two different contralateral care regimen pairings. The lens worn on the test eye was soaked overnight in either OFR or RMP and the control eye in Clear Care (CC). After lens removal, corneal staining was rated on a scale of 0 (negligible) to 100 (severe) for four peripheral quadrants and the central region, and the differential global staining score was calculated by subtracting baseline staining scores. Following the staining assessment, corneal cells were collected from the ocular surface using a non-contact irrigation system to determine ocular cell shedding rates. Differential global staining score with OFR was greater than CC with the differences being statistically significant at 30 and 60 min (p < 0.01). Maximum staining with RMP was significantly greater than OFR and peaked after 60 and 120 min of lens wear (p < 0.01). On average, 710 ± 470 ...Continue Reading

References

Jan 1, 1970·Acta Ophthalmologica·M S Norn
Mar 1, 1997·Archives of Ophthalmology·J D ArbourM C Guertin
Jul 1, 1999·Current Opinion in Ophthalmology·S C Pflugfelder
Feb 7, 2002·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Kelly K NicholsTimothy B Edrington
Jan 7, 2003·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Lyndon JonesL Gina Sorbara
Jul 16, 2005·Eye & Contact Lens·Renee J GarofaloRobin David
Apr 17, 2007·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Nicole CarntEric Papas
Jan 5, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Keith W Ward
Jul 29, 2008·Optometry : Journal of the American Optometric Association·Gary Andrasko, Kelly Ryen
Nov 11, 2008·Eye & Contact Lens·Rune L BrautasetJan P G Bergmanson
Mar 7, 2009·Eye & Contact Lens·Graeme YoungCraig A Woods
Mar 7, 2009·Eye & Contact Lens·Luigina SorbaraDesmond Fonn
Dec 26, 2009·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Charles H PowellStanley W Huth
Mar 18, 2010·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Kalika L BandamwarEric B Papas
Dec 29, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Nicole C TantiMaud B Gorbet
Sep 6, 2011·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Rachael Claire PetersonDesmond Fonn
Dec 16, 2011·Eye & Contact Lens·Jennie DiecPercy Lazon de la Jara

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Citations

Jul 16, 2013·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Nina TranMeng C Lin
Dec 3, 2014·Progress in Retinal and Eye Research·A J BronF V Bright
Jan 30, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Jalaiah VarikootyLyndon W Jones
Jul 22, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Jill Woods, Lyndon W Jones
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Fiona StapletonJames S Wolffsohn

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