Corneal stem cells and their origins: significance in developmental biology

Stem Cells and Development
Sarah B Davies, Nick Di Girolamo

Abstract

Adult corneal stem cells (SCs) have been the subject of substantial research over the past 2 decades, with promising clinical applications being devised, refined, and tried. However, there have been few studies on the early development of these cells in humans, perhaps due to ethical and practical constraints. This review highlights work that has yielded significant insights from developmental studies in the cornea and other SC repositories. This field merits further research to improve our current knowledge of the origin of SCs, their location, phenotype, function, and niche structure, as well as providing fresh insight into the pathogenesis of congenital diseases and new therapeutic avenues for treating a range of blinding corneal diseases.

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Citations

Jun 18, 2011·British Medical Bulletin·Nick Di Girolamo
May 20, 2011·Developmental Neurobiology·Gaia GestriStephan C F Neuhauss
Nov 23, 2016·The Journal of Cell Biology·Jong Kook ParkRobert M Lavker
Sep 27, 2014·World Journal of Stem Cells·Jinny J YoonTrevor Sherwin
May 8, 2020·Stem Cells Translational Medicine·Djida GhoubayVincent M Borderie
Feb 13, 2021·Genesis : the Journal of Genetics and Development·Mohd Tayyab Adil, Jonathan J Henry

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Methods Mentioned

BETA
confocal microscopy
fluorescence-activated cell sorting

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