Corneal stem cells: bridging the knowledge gap

Seminars in Ophthalmology
P Charukamnoetkanok

Abstract

Stem cell research offers hope to countless patients whose conditions have heretofore been deemed incurable. Better understanding of stem cell behaviors and functions will lead to insights into biological mysteries encompassing the fields of angiogenesis, development, tissue homeostasis, wound healing, and carcinogenesis. Clarity of vision requires smooth ocular surface on which the corneal epithelial cells undergo continuous turnover every 3 to 10 days. Tragically, many patients are blinded and devastated by severe ocular surface diseases due to limbal stem cell deficiency even though, besides opaque cornea, their eyes are otherwise healthy. Corneal stem cell transplantation offers hope by creating clear windows for these eyes; unfortunately, the long-term successful outcome remains limited. The nature of corneal epithelial stem cell is poorly understood, but many circumstantial evidences suggest the presence of "source cells" in the limbal region of the eye. Nonetheless, the precise biomarker of corneal stem cell remains elusive. The stem cell puzzle can be solved with application of the fundamental scientific method-asking salient questions at the right time and finding answers using keen observations and proper tools. Readi...Continue Reading

References

Dec 15, 1990·American Journal of Ophthalmology·H S Dua, J V Forrester
May 1, 1989·Ophthalmology·K R Kenyon, S C Tseng
Jul 1, 1988·Science·G J SpangrudeI L Weissman
Jan 1, 1988·Journal of Cell Science. Supplement·C S Potten, R J Morris
Jan 1, 1988·International Ophthalmology Clinics·J C Barber
Jan 1, 1987·The Journal of Investigative Dermatology·J R Bickenbach, K A Holbrook
Jun 1, 1984·The Journal of Investigative Dermatology·J R Bickenbach, I C Mackenzie
Sep 1, 1995·American Journal of Ophthalmology·K NishidaS Yamamoto
Jan 1, 1994·Eye·J D Zieske
May 1, 1994·Cornea·C H Dohlman, M G Doane
Nov 5, 1997·Survey of Ophthalmology·C R HicksI J Constable
Apr 17, 1998·Ophthalmology·P A NetlandC H Dohlman
Dec 23, 1998·Survey of Ophthalmology·P LeeA P Adamis
Mar 20, 1999·International Ophthalmology Clinics·F Yaghouti, C H Dohlman
Jun 3, 1999·The New England Journal of Medicine·K TsubotaJ Shimazaki
Jun 3, 1999·The New England Journal of Medicine·E J Holland, G S Schwartz
Feb 16, 2000·Progress in Retinal and Eye Research·J M WolosinA Tieng
Feb 26, 2000·Science·J M Slack
Mar 29, 2000·Survey of Ophthalmology·H S Dua, A Azuara-Blanco
Jul 13, 2000·The New England Journal of Medicine·R J TsaiJ K Chen
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·R M Lavker, T T Sun
Feb 24, 2001·Cornea·F YaghoutiC H Dohlman
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·G PellegriniM De Luca
Apr 25, 2001·Archives of Ophthalmology·M NouriC H Dohlman
Jul 6, 2001·Cell·H M BlauJ M Weimann
Aug 11, 2001·Cellular and Molecular Life Sciences : CMLS·V Pancholi
Aug 17, 2001·Current Opinion in Ophthalmology·J H ChangD T Azar
Aug 17, 2001·Current Opinion in Ophthalmology·B KhanC H Dohlman
Jan 15, 2003·Current Eye Research·J Mario WolosinMurat T Budak
Jul 31, 2003·Current Opinion in Ophthalmology·David J CarlssonMay Griffith
May 1, 1961·Archives of Ophthalmology·C HANNAJ E O'BRIEN
Oct 1, 1960·Archives of Ophthalmology·C HANNA, J E O'BRIEN

❮ Previous
Next ❯

Citations

Aug 8, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jochem VerstappenJohannes W Von den Hoff
Sep 6, 2007·International Ophthalmology·Samar A Al-Swailem
Jan 24, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Rejane Maira GóesAntonio Haddad
Apr 2, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sidney Júlio de Faria-e-SousaAntonio Haddad
Apr 2, 2020·Therapeutic Advances in Ophthalmology·Sepehr Feizi, Amir A Azari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.