Corneal Stroma Enhancement With Decellularized Stromal Laminas With or Without Stem Cell Recellularization for Advanced Keratoconus

American Journal of Ophthalmology
Jorge L Alió Del BarrioJorge L Alió

Abstract

This phase 1 study seeks to preliminarily evaluate the safety and efficacy of decellularized human corneal stromal lamina transplantation with or without autologous adipose-derived adult stem cell recellularization within the corneal stroma of patients with advanced keratoconus. Phase 1 clinical trial. Femtosecond-assisted 120-μm thickness and 9-mm diameter laminas were obtained from the anterior stroma of human donor corneas and decellularized with a sodium dodecyl sulfate solution. Autologous adipose-derived adult stem cells were obtained by elective liposuction and cultured onto both sides of the lamina. Five patients received the decellularized lamina alone and 4 patients the recellularized lamina into a femtosecond-assisted 9.5-mm diameter lamellar pocket under topical anesthesia. The total duration of follow-up was 6 months. No case showed clinical haze or scarring by month 3. Six months after surgery, patients showed a general improvement of all visual parameters, with a mean unaided visual acuity from 0.109 to 0.232 (P = .05) and corrected distance visual acuity from 0.22 to 0.356 (P = .068). Refractive sphere improved in all patients (from -4.55 diopters [D] to -2.69 D; P = .017), but refractive cylinder remained stabl...Continue Reading

Citations

Dec 21, 2018·International Journal of Molecular Sciences·Andrea PorzionatoRaffaele De Caro
May 6, 2020·Tissue Engineering. Part a·Julia Fernández-PérezMark Ahearne
Jul 23, 2020·Tissue Engineering and Regenerative Medicine·S Sharareh MahdaviAli R Djalilian
Jul 28, 2020·Eye·Marcus AngJorge L Alió
Apr 25, 2018·Journal of Tissue Engineering·Parker E LudwigJorge M Zuniga
Oct 30, 2019·Xenotransplantation·Abdulkadir IsidanBurcin Ekser
Aug 14, 2020·Journal of Refractive Surgery·Leonardo MastropasquaMario Nubile
Sep 25, 2020·Science Translational Medicine·Yonglong GuoJiansu Chen
May 16, 2019·International Ophthalmology·Emilio PedrottiGiorgio Marchini
Nov 25, 2020·Indian Journal of Ophthalmology·Mahipal S Sachdev
Dec 10, 2020·Journal of Refractive Surgery·Farideh DoroodgarJorge L Alió
Dec 2, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhen WangWenguo Cui
Sep 8, 2019·Progress in Retinal and Eye Research·Andri K RiauJodhbir S Mehta
Nov 13, 2020·Asia-Pacific Journal of Ophthalmology·M El ZarifJorge L Alió
Feb 6, 2021·Scientific Reports·Naresh PolisettiThomas Reinhard
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Lijie XieTing Huang
Feb 17, 2021·Japanese Journal of Ophthalmology·Yoshinori OieRyo Kawasaki
Feb 25, 2021·International Ophthalmology·Adriano FasoloGiorgio Marchini
Mar 13, 2021·Frontiers in Medicine·Mona El ZarifNehman Makdissy
Nov 10, 2020·Experimental Eye Research·Jorge L Alió Del BarrioJorge L Alió
Jun 16, 2021·Tissue Engineering. Part a·Andri K RiauJodhbir S Mehta
Jul 16, 2021·Therapeutic Advances in Ophthalmology·Eray AtalayNilgün Yıldırım

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