Corneal Stromal Transplantation With Human-derived Acellular Dermal Matrix for Pellucid Marginal Corneal Degeneration: A Nonrandomized Clinical Trial

Transplantation
Xiaodan JiangXuemin Li

Abstract

To investigate the transparency, biocompatibility, and safety of human-derived acellular dermal matrix for application in corneal stromal transplantation. Twenty-four patients (24 eyes) with pellucid marginal corneal degeneration were enrolled, and intrastromal keratoplasty was performed with human-derived acellular dermal matrix. The ocular symptoms and signs as well as graft characteristics were evaluated at baseline and at 1 day, 1 week, and 1, 3, and 6 months postoperatively. Photography by a slit lamp, topography by Pentacam, anterior segment-optical coherence tomography, and corneal confocal microscopy were conducted at baseline and during the follow-up period. Postoperative discomfort was relieved during the follow-up period. No abnormal ocular signs were observed at 6 months, indicating the safety of the procedure. Desirable and improved transparency of the grafts was demonstrated, and all the grafts healed without dissolution or fall at 6 months postoperatively. Reepithelization was completed, and confocal microscopy revealed that keratocytes and nerves repopulated in all the grafts at 6 months postoperatively. The thinning of the marginal corneal stroma was eliminated following the transplantation, and the curvature a...Continue Reading

References

Aug 15, 1990·American Journal of Ophthalmology·G A VarleyJ H Krachmer
Feb 1, 1984·American Journal of Ophthalmology·J I Schnitzer
Dec 14, 2007·Biomaterials·Wenguang LiuFengfu Li
Apr 23, 2008·Pediatric Research·Ajay ShahElizabeth Orwin
Jan 23, 2009·Journal of Biomechanics·Maurizio VentrePaolo A Netti
May 30, 2009·Journal of the American College of Surgeons·Jia Gang HanXin Qing Yang
Dec 28, 2010·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Amit JinabhaiClare O'Donnell
Apr 16, 2011·Journal français d'ophtalmologie·E GuilbertV Borderie
Jun 18, 2011·Eye·N JiráskováM Kalfertova
Jul 21, 2012·The Ocular Surface·May GriffithThomas Armin Fuchsluger
Mar 13, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M-C ZhangH-T Xie
May 23, 2015·Clinical and Translational Science·Oleksiy BuznykMay Griffith
Jun 16, 2015·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Raul MartinMichael J Doughty
Jul 27, 2015·American Journal of Ophthalmology·Aaron T ChanClara C Chan
Nov 21, 2015·Tissue Engineering. Part C, Methods·Jie ZhangDipika V Patel
Dec 4, 2015·JAMA Ophthalmology·Philippe GainGilles Thuret
Apr 22, 2016·Journal of Internal Medicine·M GriffithI Brunette
May 24, 2016·Journal of Functional Biomaterials·Borja Salvador-Culla, Paraskevi E Kolovou
Aug 27, 2016·World Journal of Virology·Massimo De Paschale, Pierangelo Clerici
Sep 1, 2017·Scientific Reports·Yongliang LinYifei Wang
Sep 16, 2017·Journal of Current Ophthalmology·Kazem AmanzadehEbrahim Jafarzadepur

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.