Corneoscleral necrosis after episcleral Au-198 brachytherapy of uveal melanoma

Retina
Imtiaz A ChaudhryMilton Boniuk

Abstract

To describe the risk factors for the development of corneoscleral necrosis (CSN) and its management in patients with primary choroidal or ciliochoroidal melanoma who underwent episcleral Au-198 brachytherapy. Clinical records of patients with symptoms of dry eye, foreign body sensation, pain, and evidence of CSN after Au-198 brachytherapy for uveal melanoma treated over a 22-year period were reviewed retrospectively. Risk factors for the development of CSN were identified and various methods of management were evaluated. The data were analyzed using multivariant analysis. A P < 0.05 was taken as a level of statistical significance. Of the 202 eyes of 202 patients treated with Au-198 radioactive plaque, 15 (7.4%) patients with symptomatic complaints of dry eye and pain showed evidence of CSN. First signs were noted as early as 1 month to as late as 5 years (median time 5 months) after the treatment. Risk factors for the development of CSN included tumor thickness greater than 6 mm and ciliary body involvement (P < 0.05). Associated risk factor included intraocular pressure greater than 21 mmHg. Four patients required conservative management, 11 patients required scleral patch and/or conjunctival flaps, and 6 eyes eventually requ...Continue Reading

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Citations

Apr 11, 2012·Retina·Kelly L ClassicJose S Pulido
Feb 13, 2016·Advanced Healthcare Materials·Yongfeng ZhaoYongjian Liu
Aug 26, 2009·Clinical & Experimental Ophthalmology·Natalie Walsh-Conway, R Max Conway
Jan 26, 2013·Ophthalmology·Swathi KalikiJerry A Shields
Feb 7, 2019·Journal of Clinical Pathology·Mark Hankins, Curtis Edward Margo
Dec 24, 2018·Ocular Oncology and Pathology·Diane T SiegelHans E Grossniklaus
Apr 19, 2021·Clinical & Experimental Ophthalmology·Leyla JabbarliNikolaos E Bechrakis
Jul 23, 2021·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Samira KamraniSamaneh Hashemi

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