Corona virus versus existence of human on the earth: A computational and biophysical approach

International Journal of Biological Macromolecules
Zainy ZehraAsimul Islam

Abstract

SARS-CoV-2 has a positive sense RNA genome of 29.9 kb in size, showing high sequence similarity to the BAT-CoV, SARS-CoV, MERS-CoV. SARS-CoV-2 is composed of 14 open reading frames (ORFs), which encodes for a total of 27 proteins divided into structural and non-structural proteins (NSPs). The fundamental structural protein-encoding genes are a spike protein (S) gene, envelope protein (E) gene, a membrane protein (M) gene, and a nucleocapsid protein (N) gene. They make about 33% of the entire genome and are vital for the viral life cycle. Rest 67% is distributed among different NSPs (such as Mpro, helicase, and RNA-dependent RNA polymerase) encoding genes across the ORFs, which are involved in virus-cell receptor interactions during viral entry. Researchers are trying to formulate vaccines, therapeutic antibodies or protein-targeted antiviral drugs to control the spread. This review proceeds stepwise through the COVID-19 outbreak, structural and genomic organization, entry mechanism, pathogenesis, and finally highlighting the essential proteins involved at each step that might be potential targets for drug discovery. Currently, approved treatment modalities consist of only supportive care and oxygen supplementation. This review ...Continue Reading

Citations

Dec 1, 2020·Acta Tropica·Sanjay Kumar Mishra, Timir Tripathi
Oct 28, 2020·Materials Chemistry and Physics·Bankole I OladapoMohsen Zahedi
Mar 5, 2021·Computers in Biology and Medicine·Muhammad I IsmailTamer M Ibrahim
Mar 14, 2021·International Journal of Biological Macromolecules·Alexander I DenesyukKonstantin Denessiouk
Mar 25, 2021·Journal of Biomolecular Structure & Dynamics·Shariq ShamsiAnas Shamsi
Oct 16, 2020·International Journal of Biological Macromolecules·Konstantin DenessioukAlexander I Denesyuk
Nov 2, 2021·Journal of Biomolecular Structure & Dynamics·Karim M ElSawyLeo S D Caves

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Methods Mentioned

BETA
PCR
X ray

Software Mentioned

SOLIDARITY

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