Coronary 64-slice computed tomographic angiography models employing aortic root and selective catheter directed contrast enhancement in swine: technical feasibility and preliminary results using 3D and 4D reconstructions

The International Journal of Cardiovascular Imaging
Kostaki G BisWilliam O'Neill

Abstract

The technical feasibility of combining catheter directed coronary enhancement and multidetector computed tomographic angiography (MD-CTA) is presented in a swine model at various cardiac and injection rates. A 64-slice CT scanner was used under animal IRB approval in four sedated swine. Common femoral venous/arterial access with a 5 Fr micropuncture kit was ultrasound guided. Investigational 5 Fr diffusion-tip pigtail [aortic root (AR)-MD-CTA] and conventional 5 Fr coronary [selective (S)-MD-CTA] catheters were positioned on the CT table with c-arm fluoroscopy. AR-MD-CTA commenced 1-2 s after injection of 50 cc Visipaque mixed with 50 cc NS at 6 cc/s (n=3), 8 cc/s (n=5) or 10 cc/s (n=7) (HR=120, 100, 90, 80 or 65 bpm). S-MD-CTA (right and left, n=4) (HR= 90, 80, or 65 bpm) commenced 1-2 s after injection of 5 cc Visipaque mixed with 5 cc NS (1 cc/s). IV-MD-CTA (n=4) (HR=80 bpm) commenced 5 or 10 s after aortic peak density with 100 cc Visipaque (5 cc/s) and 50 or 75 cc NS (5 cc/s) flush. Conventional angiography (n=2) used standard protocol. MD-CTA was performed with the following parameters: collimation 0.6 mm, tube rotation time 0.3 s, table feed/rotation 3.8 mm, scan time 10-12 s, tube voltage 120 kVp, effective mAs 850, pit...Continue Reading

References

Sep 18, 2001·Lancet·K NiemanP J de Feyter
Jun 2, 2004·Journal of Magnetic Resonance Imaging : JMRI·Christoph R Becker, Andreas Knez
Jun 12, 2004·European Heart Journal·Eugenio MartuscelliFrancesco Romeo
Jun 15, 2004·Journal of the American College of Cardiology·Nico R MolletPim J de Feyter
Apr 29, 2005·The International Journal of Cardiovascular Imaging·Kostaki G BisWilliam O'Neill
Aug 2, 2005·Journal of the American College of Cardiology·Gilbert L RaffJames A Goldstein

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