Abstract
Coronary artery calcification (CAC) was once thought to be a passive, degenerative, and quiescent development of disease. However, it has now been shown to be an active process associated with atherosclerosis that is stimulated by inflammatory pathways. Calcification forms within the intimal and medial layers of the vessel wall by way of mechanisms similar to bone development. A variety of imaging modalities have been used to identify and characterize CAC, from early microcalcifications to well-developed fibroatheromas that have calcified. There are sex and race differences in prevalence and development of CAC, and medical therapies such as statin and warfarin use exhibit pro-calcific effects on the vessel wall. Effective medical treatment of CAC has yet to be established; therefore a greater understanding of the factors that induce calcification is needed to develop appropriate therapeutic strategies.
Citations
Nov 2, 2018·Current Cardiology Reviews·Daniel AzpiazuRicardo Villa-Bellosta
Jul 30, 2019·Frontiers in Pharmacology·Lin YuanXiaotian Chang
Feb 14, 2020·Radiology·Michael W Vannier
Jan 31, 2019·Scientific Reports·F Bartoli-LeonardR Weston
May 8, 2020·Scientific Reports·Tao YaoZhichao Liu
Jan 9, 2019·Frontiers in Cardiovascular Medicine·Francesca Bartoli-LeonardRia Weston
Jun 27, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Kamyar Asadipooya, Ada Weinstock
Nov 23, 2019·Current Atherosclerosis Reports·Hong Loan NguyenTina Shah
Aug 24, 2020·JACC. Cardiovascular Imaging·Najdat BazarbashiRishi Puri
Dec 16, 2020·IScience·Lei WangStefan Offermanns
Jan 12, 2021·Frontiers in Cardiovascular Medicine·Runmin LaiHao Xu
Dec 4, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xuan XiaoChi Zhang
Feb 28, 2021·Journal of Magnetic Resonance Imaging : JMRI·Lichen ZhangUNKNOWN CARE-II investigators
Mar 9, 2021·Advances in Nutrition·M Kyla SheaSarah L Booth
Apr 15, 2021·Stem Cell Research & Therapy·Wenqian WeiShu Rong
Apr 23, 2021·Future Cardiology·Antonio NennaMassimo Chello
Feb 25, 2021·Menopause : the Journal of the North American Menopause Society·Wenqian YuNa Li
May 13, 2021·European Cardiology·Alberto J Lorenzatti
May 22, 2021·Aging·Jin NiuJianming Pei
Jul 30, 2021·Frontiers in Neurology·Krista NuotioPerttu J Lindsberg