Coronary arteries hemodynamics: effect of arterial geometry on hemodynamic parameters causing atherosclerosis.

Medical & Biological Engineering & Computing
Kelvin K L WongDhanjoo Ghista

Abstract

Coronary arteries have high curvatures, and hence, flow through them causes disturbed flow patterns, resulting in stenosis and atherosclerosis. This in turn decreases the myocardial flow perfusion, causing myocardial ischemia and infarction. Therefore, in order to understand the mechanisms of these phenomena caused by high curvatures and branching of coronary arteries, we have conducted elaborate hemodynamic analysis for both (i) idealized coronary arteries with geometrical parameters representing realistic curvatures and stenosis and (ii) patient-specific coronary arteries with stenoses. Firstly, in idealized coronary arteries with approximated realistic arterial geometry representative of their curvedness and stenosis, we have computed the hemodynamic parameters of pressure drop, wall shear stress (WSS) and wall pressure gradient (WPG), and their association with the geometrical parameters of curvedness and stenosis. Secondly, we have similarly determined the wall shear stress and wall pressure gradient distributions in four patient-specific curved stenotic right coronary arteries (RCAs), which were reconstructed from medical images of patients diagnosed with atherosclerosis and stenosis; our results show high WSS and WPG reg...Continue Reading

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Citations

Jan 15, 2022·Medical & Biological Engineering & Computing·Roozbeh Salajeghe, Mohammad Said Saidi

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Methods Mentioned

BETA
feature extraction
coronary bypass

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