Coronary arteriography with an oxygenated contrast medium: cardiac effects in dogs with and without acute ischemic heart failure

Academic Radiology
H K PedersenH Refsum


We investigated the possible cardiac effects of oxygen addition to contrast media (CM) during coronary arteriography in dogs that did and did not have ischemic heart failure. Acute ischemic heart failure was induced by injecting small plastic microspheres into the left coronary artery of 18 dogs. Hemodynamic and electrophysiologic measurements were performed during a single injection before and during heart failure and during a single injection and five rapidly repeated CM injections during heart failure. Iohexol supplemented with electrolytes (iohexol + electrolytes = IPE), oxygenated IPE (IPE+O), Ringer acetate, and oxygenated Ringer acetate were injected into the left coronary artery. Single injections of IPE and IPE+O induced small hemodynamic and electrophysiologic effects. However, repeated injections of IPE and IPE+O increased left ventricular inotropy (maximum value of the first derivative of the left ventricular pressure) by 36% and 39%, reduced heart rate by 7% (for both), and lengthened QTc time (corrected QT interval) by 39 and 38 msec, respectively. A comparison of IPE and IPE+O revealed no statistically significant differences. Although electrolyte addition to nonionic CM may reduce the risk of cardiac complicatio...Continue Reading


May 1, 1991·Progress in Cardiovascular Diseases·M R Franz
Mar 1, 1989·Cardiovascular and Interventional Radiology·K LevorstadT Aakhus
Apr 1, 1989·Investigative Radiology·K Hayakawa, K Yamashita
Sep 1, 1988·Investigative Radiology·R W Katzberg
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Apr 1, 1984·Journal of Clinical Pharmacology·E M Vaughan Williams
Jun 1, 1982·Clinical Physiology·O A Smiseth, O D Mjøs

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Feb 6, 1999·European Journal of Radiology·S K MorcosJ O Karlsson

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