Coronary artery calcium severity grading on non-ECG-gated low-dose chest computed tomography: a multiple-observer study in a nationwide lung cancer screening registry

European Radiology
Young Joo SuhHwan Seok Yong

Abstract

To identify the optimal method for evaluation of coronary artery calcium (CAC) severity on non-electrocardiogram-gated low-dose chest computed tomography (LDCT) in a nationwide lung cancer screening registry. A total of 256 subjects were retrospectively enrolled from participants of the Korean Lung Cancer Screening (K-LUCAS) project (an LDCT lung cancer screening registry for high-risk individuals). Four board-certified cardiothoracic radiologists independently assessed CAC severity using four different scoring methods (visual assessment, artery-based grading, segment-involvement grading, and segment-based grading) and classified severity for each case using all four methods as none, mild, moderate, or severe. Agreements between the four observers for CAC category classification and between the four different scoring methods for the same observer were assessed by Fleiss kappa statistics. Evaluation time for CAC grading was compared between observers and between grading methods. Interobserver agreement was moderate for visual assessment (Fleiss kappa 0.451) and substantial for the other three methods (Fleiss kappa 0.673-0.704). Agreement between the four grading methods for the same observer was substantial for three observers (...Continue Reading

References

Sep 18, 2007·Journal of the American College of Cardiology·James K MinTracy Q Callister
Mar 22, 2008·AJR. American Journal of Roentgenology·Sung Mok KimBong-Keun Choe
May 24, 2011·European Radiology·Peter C JacobsYolanda van der Graaf
Jul 1, 2011·The New England Journal of Medicine·UNKNOWN National Lung Screening Trial Research TeamJoRean D Sicks
Feb 24, 2012·AJR. American Journal of Roentgenology·Peter C JacobsWillem P T M Mali
Jun 19, 2013·JACC. Cardiovascular Imaging·Onno M MetsPim A de Jong
Feb 15, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J Lortet-TieulentF Bray
Mar 16, 2016·Circulation·Ryan J KoeneSuma H Konety
Dec 21, 2017·AJR. American Journal of Roentgenology·Brett W CarterReginald F Munden
Feb 7, 2018·IEEE Transactions on Medical Imaging·Nikolas LessmannIvana Isgum
May 12, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Michael J ReiterApril Plank
Jul 3, 2018·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Ji Won LeeJuntae Lim
Nov 6, 2018·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Eun Young KimYeol Kim
Feb 20, 2019·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jaeho LeeDuk Hyoung Lee
Feb 23, 2019·IEEE Transactions on Medical Imaging·Bob D de VosIvana Isgum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.