Coronary artery disease risk in young women with polycystic ovary syndrome

Oncotarget
Dah-Ching DingFung-Chang Sung

Abstract

Women with polycystic ovary syndrome are characterized by obesity, menstruation irregularity, hirsutism and infertility, and prevalent with cardiometabolic comorbidities, but population-based studies on the risk of developing coronary artery disease are limited. From claims data of the Taiwan National Health Insurance, we identified 8048 women with polycystic ovary syndrome aged 15-49 years newly diagnosed in 1998-2013, and 32192 women without the syndrome and CAD as controls, frequency matched by age and diagnosis date. By the end of 2013, after a mean follow-up period of 5.9 years, the overall incidence of coronary artery disease was 63% higher in women with polycystic ovary syndrome than in controls (2.25 vs. 1.38 per 1000 person-years). The adjusted hazard ratio [aHR] of coronary artery disease was 1.44 (95% confidence interval (CI) = 1.14-1.81) for women with polycystic ovary syndrome, compared with controls. Hazards of coronary artery disease were significant during follow-up periods of 3-4 years (aHR = 1.52, 95% CI = 1.00-2.30) and of 5-9 years (aHR = 1.58, 95% CI = 1.07-2.32). The incidence of coronary artery disease increased further in those with cardiometabolic comorbidities. Among women with polycystic ovary syndrom...Continue Reading

References

Jul 23, 1998·Journal of Clinical Epidemiology·T PierpointH S Jacobs
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Caren G SolomonJoann E Manson
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Rose C ChristianLorraine A Fitzpatrick
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Ricardo AzzizBulent O Yildiz
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Aug 31, 2006·The Journal of Clinical Endocrinology and Metabolism·Ricardo AzzizUNKNOWN Androgen Excess Society
Jan 25, 2007·Menopause : the Journal of the North American Menopause Society·Andrew J KrentzElizabeth Barrett-Connor
Dec 20, 2007·The Journal of Clinical Endocrinology and Metabolism·Thomas M BarberMark I McCarthy
May 28, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·Ebenezer O BabalolaJohn B Gebhart
Oct 29, 2010·The Journal of Clinical Endocrinology and Metabolism·Erica T WangMarcelle I Cedars
Jun 2, 2011·Human Reproduction Update·Konstantinos A ToulisBasil C Tarlatzis
Jun 28, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Tetsuya Ohira, Hiroyasu Iso
Jul 12, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Jun Hata, Yutaka Kiyohara
Jun 5, 2015·Heart·Prachi BhatnagarNick Townsend
Jul 21, 2015·JAMA Internal Medicine·Ann W Hsing, John P A Ioannidis
Jan 27, 2016·Circulation·UNKNOWN Writing Group MembersUNKNOWN Stroke Statistics Subcommittee
Apr 20, 2016·Frontiers in Physiology·Samer El HayekGeorges Daoud
Dec 3, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Kazuyuki YahagiRenu Virmani
Jan 7, 2017·Circulation Research·Mark R Thomas, Gregory Y H Lip
Jan 8, 2017·Clinical and Experimental Nephrology·Hideki Fujii, Nobuhiko Joki
May 2, 2017·Climacteric : the Journal of the International Menopause Society·M N Gunning, B C J M Fauser

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Citations

Jul 19, 2019·Heart·Laura Young, Leslie Cho
Aug 7, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Fahimeh Ramezani TehraniEnrico Carmina
Oct 23, 2019·Clinical Endocrinology·Cindy MeunUNKNOWN CREW consortium
Mar 19, 2020·Reproductive Biology and Endocrinology : RB&E·Mina AmiriEnrico Carmina
Jun 26, 2020·Journal of Clinical Medicine·Tsung-Hsien LeeJames Cheng-Chung Wei
Oct 20, 2020·Frontiers in Medicine·Cheng-Hsuan WuJames Cheng-Chung Wei
Aug 30, 2018·Current Vascular Pharmacology·Eleni Armeni, Irene Lambrinoudaki
Sep 22, 2018·Journal of Cardiovascular Medicine·Susanna SciomerGiuseppe Mercuro
Feb 2, 2021·Endocrinology and Metabolism Clinics of North America·Laura G Cooney, Anuja Dokras
Jul 3, 2021·International Journal of Molecular Sciences·Elisa LeporeVittorio Unfer
Jun 2, 2021·The Journal of Clinical Endocrinology and Metabolism·Thomas R BerniD Aled Rees
Aug 31, 2021·European Heart Journal·Frank L J VisserenUNKNOWN ESC Scientific Document Group
Sep 25, 2021·European Journal of Preventive Cardiology·Frank L J VisserenUNKNOWN ESC Scientific Document Group

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