PMID: 11605998Oct 19, 2001Paper

Coronary artery distensibility and compensatory vessel enlargement--a novel parameter influencing vascular remodeling?

Basic Research in Cardiology
A JeremiasA C Yeung

Abstract

Vascular remodeling implies the concept of compensatory vessel enlargement to preserve luminal dimensions during atheromatous plaque development. However, negative remodeling, i.e. vessel shrinkage in response to plaque accumulation has also been described. So far, the factors influencing positive or negative remodeling are uncertain. We hypothesized that vascular distensibility, a measure of vessel compliance, is related to compensatory enlargement. In 58 patients undergoing intravascular ultrasound interrogation of a de novo lesion prior to coronary intervention, the cross-sectional vessel area (VA), lumen area (LA) and plaque area (PA = VA minus LA) were measured at end diastole and end systole at the lesion site and at the proximal and distal reference segments. Positive remodeling was defined to be present when the VA at the lesion was > 1.05 times larger than that at the proximal reference (group A), negative remodeling when the VA at the lesion was < 0.95 of the reference site (group C) and in-between was considered to be intermediate (group B). Vessel compliance was measured by calculating vascular distensibility. Results showed a similar LA at the lesion site in all groups (4.18+/-2.18 vs. 4.36+/-1.19 vs. 3.74+/-1.81 m...Continue Reading

Citations

Apr 28, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Kai LinJames C Carr
Mar 9, 2007·Medical Hypotheses·Yiannis S Chatzizisis, George D Giannoglou
Jul 5, 2003·The American Journal of Cardiology·Kenichi FujiiJeffrey W Moses
Dec 6, 2005·International Journal of Cardiology·Zenon S KyriakidesEftichia Sbarouni
Aug 30, 2005·The American Journal of Cardiology·Michael R WardKazuo Kimura
Jan 20, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Haiyan LiJonathan M Tobis
May 17, 2006·Journal of Cardiovascular Pharmacology and Therapeutics·Hanumanth K ReddySuresh C Tyagi

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