Coronary artery thrombosis associated with Paclitaxel in advanced ovarian cancer.

Korean Circulation Journal
Sang-Ho ParkWon-Yong Shin

Abstract

A 63-year-old woman was diagnosed with ovarian cancer and peritoneal carcinomatosis. The day after paclitaxel was administered, an acute myocardial infarction occurred. Emergency coronary angiography revealed a filling defect in the left main coronary artery and total occlusion in the distal left anterior descending coronary artery, with no luminal irregularity or narrowing. Intravascular ultrasonography showed no significant plaque in the left main coronary artery. A thrombophilia work-up was negative, and the patient was treated with tirofiban, clopidogrel, and aspirin. The follow-up coronary angiogram showed that the occlusion of the distal obtuse marginal branch and distal left anterior descending artery had cleared. Paclitaxel has been associated with acute myocardial infarction. However, the pathogenesis of myocardial infarction associated with paclitaxel is not known. This case raises the possibility that paclitaxel can induce coronary artery thrombosis, resulting in myocardial infarction.

References

Sep 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E K RowinskyR C Donehower
Apr 13, 1995·The New England Journal of Medicine·E K Rowinsky, R C Donehower
May 31, 2002·Internal Medicine Journal·J B SelvanayagamR J McRitchie

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Citations

Mar 20, 2021·Internal Medicine Journal·Benjamen WangRonen Gurvitch

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