PMID: 6270513Apr 1, 1981Paper

Coronary artery vasospasm and emotional stress: a hypothetical link to atherosclerosis

Medical Hypotheses
G E Billman


A large body of evidence suggests that psychosocial behavior may contribute to the formation of coronary heart disease. It is proposed that emotionally-induced coronary vasospasm leads to the development of coronary atherosclerosis. This hypothesis is based on two observations: a) coronary vasospasm is present at the site of organic lesions and may be antecedent to the development of the atherosclerotic plaque, and b) emotional stress results in an alpha adrenergically mediated increase in coronary vascular resistance.


Mar 1, 1979·Psychosomatic Medicine·F A ErnstC A Sandman
Oct 1, 1978·Circulation·J A BlumenthalL W Thompson
Dec 1, 1975·Circulation Research·D H Cohen, P A Obrist
Apr 12, 1973·The New England Journal of Medicine·P B OlivaR G Pluss
Feb 1, 1967·Circulation Research·E O Feigl
Feb 1, 1981·Circulation Research·G E Billman, D C Randall
Jul 1, 1980·The American Journal of Cardiology·R N MacAlpin
Jan 1, 1980·Annual Review of Medicine·G J Miller

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Jan 1, 1987·Medical Hypotheses·A Yabrov
Jun 1, 1983·British Journal of Obstetrics and Gynaecology·M Briggs, M Briggs

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