Coronary atherosclerotic lesions in human immunodeficiency virus-infected patients: a histopathologic study.

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Robert G MichelettiJudith S Currier

Abstract

Studies suggest human immunodeficiency virus-positive (HIV+) patients have an increased risk of coronary artery disease (CAD), yet little is known about the histopathology, severity, or distribution of lesions. The coronary arteries of 66 deceased AIDS patients and 19 HIV controls (age <55) were dissected and graded for percent luminal stenosis by intimal lesions, percent of intima involved with lipid, and extent of intimal calcification on a scale of 0 to 3. Medical histories, antiretroviral therapies, and CAD risk factors were reviewed. HIV+ patients were older than controls (P=.06), and more were male (P=.02). Thirty-five percent of HIV+ patients had stenosis >or=75% of at least one artery. Compared to controls, HIV+ patients had three times greater odds of stenosis >or=75%, controlling for age and sex (one-sided P=.03). Older age and male sex were also risk factors (one-sided P<.001). HIV seropositivity was associated with increased plaque lipid content (one-sided P=.02) and calcification (one-sided P=.08). Duration of HIV infection, antiretroviral therapy, and immune status did not predict severe disease in multivariate analyses. Previously unreported patterns of dystrophic calcification were observed in HIV+ patients and ...Continue Reading

References

Apr 1, 1995·American Heart Journal·H O VenturaD D Stapleton
Aug 1, 1993·Journal of the American College of Cardiology·A JosephJ Kupersmith
May 1, 1993·Research in Virology·P PatonR Tete
Nov 15, 1996·Circulation·M C Fishbein, R J Siegel
Jun 22, 1999·The New England Journal of Medicine·G D Sloop
Aug 3, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Daniel KleinStephen Sidney
Dec 20, 2002·Nature·Peter Libby
Jul 14, 2004·Circulation·John C WangRichard E Kuntz
May 5, 2005·The Journal of Cardiovascular Nursing·F Patrick RobinsonGeorge T Kondos
Mar 21, 2006·Journal of the American College of Cardiology·Jeroen P H van WijkAndy M Hoepelman
Nov 2, 2006·PLoS Biology·Zahedi MujawarDmitri Sviridov
Nov 11, 2006·Circulation Research·Rebecca C JohnsonJoseph Loscalzo
Apr 27, 2007·The New England Journal of Medicine·UNKNOWN DAD Study GroupJens D Lundgren

❮ Previous
Next ❯

Citations

Feb 24, 2011·Current HIV/AIDS Reports·Louis H Miller, John T Coppola
May 8, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Rudolph SchutteLeoné Malan
Dec 3, 2009·Journal of Leukocyte Biology·Suzanne M CroweMichael Bukrinsky
Nov 10, 2011·The Journal of Veterinary Medical Science·Takayuki SuzukiTetsuo Nunoya
Feb 23, 2010·Enfermedades infecciosas y microbiología clínica·Carlos Alonso-Villaverde Lozano
Feb 3, 2009·International Journal of Cardiology·Salvatore PatanèAntonio Albanese
Dec 25, 2015·Journal of Clinical Lipidology·Terry A JacobsonUNKNOWN NLA Expert Panel
Sep 15, 2015·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Michael C Fishbein, Gregory A Fishbein
Aug 1, 2015·Emergency Medicine Clinics of North America·Thuy Van Pham, Mercedes Torres
Oct 9, 2012·International Journal of Cardiology·Chrysostomos A MavroudisRoby D Rakhit
Feb 13, 2015·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Amish A Patel, Matthew J Budoff
May 7, 2014·International Journal of Cardiology·Ricardo O EscárcegaAlfred A Bove
Sep 24, 2011·Current Problems in Diagnostic Radiology·Ahmed M GharibColleen Hadigan
Sep 5, 2009·American Journal of Hypertension·Rudolph SchutteLeoné Malan
Aug 24, 2016·The Journal of Infectious Diseases·Jose GutierrezSusan Morgello
Dec 8, 2010·Angiology·Kosmas I ParaskevasDimitri P Mikhailidis
May 10, 2013·Journal of Cardiovascular Medicine·Davide GibelliniMaria Carla Re
Oct 7, 2011·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalGabriella Comunián-Carrasco
Dec 22, 2010·International Reviews of Immunology·Daniele PastoriIvano Mezzaroma
Mar 3, 2011·The American Journal of Tropical Medicine and Hygiene·Florence MasaisaJan Philippé
Jun 26, 2013·American Journal of Therapeutics·Michael G Barakat, Rohit R Arora
Aug 6, 2009·Archives of Pathology & Laboratory Medicine·Gregory A Fishbein, Michael C Fishbein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.