PMID: 9184299Jun 1, 1997Paper

Coronary AVE micro stents: serial quantitative angiography and histology in a canine model

Catheterization and Cardiovascular Diagnosis
E V PomerantsevS Stertzer

Abstract

The AVE Micro Stent (AVE Inc., Santa Rosa, CA) is composed of helically welded 3 mm long, zigzag crowns with stent lengths from 6 to 39 mm and diameters from 2.5 to 4.5 mm. Quantitative coronary angiography and histologic analyses of acute and chronic implantation were obtained in 52 stented coronary segments of 18 dogs. Three hearts with 8 stented coronary segments were harvested after 24 hr, 3 hearts with 9 stented segments were harvested after 2 weeks, 6 hearts with 15 stented segments were harvested at 8 weeks, and 6 hearts with 20 stented segments were harvested at 24 weeks post-deployment. There were no procedural complications, deaths, or acute vessel closures. The average lumen diameter of the stented segment was largest at 2 weeks (3.3 +/- 0.3 mm). The smallest average diameters were observed at 8 weeks after the stent deployment (2.7 +/- 0.4, P < 0.05) with an increase again at 24 weeks (2.9 +/- 0.6). The pre-explant percent of stenosis was <30% in all animals. Histologically, a peak of inflammation was visible at 2 weeks; however, the extent of luminal narrowing reached its peak at 8 weeks and the lumen dimension increased somewhat at 24 weeks. The degree of intimal thickening remained relatively constant throughout ...Continue Reading

References

Mar 1, 1992·Catheterization and Cardiovascular Diagnosis·W R HermansP W Serruys
Oct 1, 1991·Catheterization and Cardiovascular Diagnosis·W H LeungE L Alderman
Dec 1, 1991·Circulation·W H LeungE L Alderman
Nov 1, 1990·Catheterization and Cardiovascular Diagnosis·W H LeungM L Stadius
Aug 1, 1987·Circulation·R A SchatzS R Reuter
Jan 1, 1994·Catheterization and Cardiovascular Diagnosis·A AnwarR K Myler

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Citations

Jun 1, 1997·Catheterization and Cardiovascular Diagnosis·M S Ganim, R W Smalling
Nov 19, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Harry C LoweStephen N Oesterle

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