Coronary compliance in patients following orthotopic heart transplantation. An intravascular ultrasound study

European Heart Journal
S KerberG Breithardt

Abstract

The aim of this study was to investigate coronary compliance in patients early and 71.8 weeks after orthotopic heart transplantation. Thirty patients (mean age 51.4 years, women n = 6) underwent coronary angiography early after orthotopic heart transplantation (mean interval 11.6 +/- 5.5 weeks), by which time 12 recipients had already been treated for episodes of rejection. A total of 153 different coronary segments were investigated using a mechanical 30 MHz intravascular ultrasound system. In all segments, the intimal index and the circumferential extension of the vessel wall, which had a three-layered appearance, were assessed. Systolic-diastolic changes in area, and pressure with respect to vessel wall area, were used to study normalized compliance. All measurements were repeated in a subgroup of 13 patients 71.8 +/- 10.7 weeks after transplantation. At the first investigation, the mean intimal index of all estimated cross-sectional areas was 0.07 +/- 0.10. The mean circumferential extension of the 'three-layered' coronary vessel wall was 74 degrees +/- 101 degrees. No correlation could be found between normalized compliance and the intimal index (r = -0.322, P < 0.001) or between normalized compliance and the circumferenti...Continue Reading

Citations

Jul 1, 1998·Herz·M C DengH H Scheld
May 22, 2002·Journal of the American College of Cardiology·James A ShawAnthony M Dart
Jul 8, 2008·Journal of Biomechanical Engineering·Dehong ZengDimos Poulikakos
Jun 16, 2014·European Journal of Radiology·Kai LinJames C Carr

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