Coronary Computed Tomographic Angiography-Derived Fractional Flow Reserve for Therapeutic Decision Making

The American Journal of Cardiology
Christian TescheU Joseph Schoepf

Abstract

This study investigated the performance of coronary computed tomography angiography (cCTA) with cCTA-derived fractional flow reserve (CT-FFR) compared with invasive coronary angiography (ICA) with fractional flow reserve (FFR) for therapeutic decision making in patients with suspected coronary artery disease (CAD). Seventy-four patients (62 ± 11 years, 62% men) with at least 1 coronary stenosis of ≥50% on clinically indicated dual-source cCTA, who had subsequently undergone ICA with FFR measurement, were retrospectively evaluated. CT-FFR values were computed using an on-site machine-learning algorithm to assess the functional significance of CAD. The therapeutic strategy (optimal medical therapy alone vs revascularization) and the appropriate revascularization procedure (percutaneous coronary intervention vs coronary artery bypass grafting) were selected using cCTA-CT-FFR. Thirty-six patients (49%) had a functionally significant CAD based on ICA-FFR. cCTA-CT-FFR correctly identified a functionally significant CAD and the need of revascularization in 35 of 36 patients (97%). When revascularization was deemed indicated, the same revascularization procedure (32 percutaneous coronary interventions and 3 coronary artery bypass graft...Continue Reading

Citations

Jun 11, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira KurataTeruhito Mochizuki
Oct 31, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Giuseppe Biondi-ZoccaiFrancesco Nudi
Jul 6, 2020·The International Journal of Cardiovascular Imaging·Verena BrandtChristian Tesche
May 24, 2020·Medicine·Jun PangQingwei Chen
Feb 11, 2020·Frontiers in Cardiovascular Medicine·Nils HampeIvana Išgum
Aug 11, 2019·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·K R SiegersmaJ W Verjans
Feb 9, 2021·Journal of X-ray Science and Technology·Wenting ShenXiaomei Zhu
Mar 26, 2021·European Radiology Experimental·Akos Varga-Szemes, Pal Suranyi

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