Coronary diameter and vasodilator function in children following arterial switch operation for complete transposition of the great arteries

The American Journal of Cardiology
Daniel R TurnerT P Singh

Abstract

Coronary reimplantation during arterial switch operation (ASO) may affect coronary artery growth and function during childhood. The purpose of this study was to assess coronary artery diameter and regional myocardial blood flow (MBF) and myocardial flow reserve (MFR) in children after neonatal ASO. We measured proximal diameters of left anterior descending (LAD), left circumflex, and posterior descending coronary arteries on coronary angiogram in 12 children (median age 11 years, range 7.6 to 15.1) with a history of neonatal ASO. These children then underwent cardiac positron emission tomographic imaging using nitrogen-13 ammonia to assess MBF at baseline and during intravenous adenosine hyperemia in regions supplied by these 3 coronary arteries. Coronary artery z-scores were within normal range (-2.0 to 2.0) for 32 of 36 coronary arteries. MFR (ratio of hyperemic to basal MBF) was normal (>2.5) in all myocardial regions in 10 of 12 patients. The remaining 2 patients, 1 with a dual LAD and 1 with LAD origin from the right coronary artery, had generalized impairment of hyperemic MBF (<2.0 ml/g/min) and low MFR (<2.5). Coronary artery z-scores and MFR in corresponding myocardial territories were not correlated (r = 0.15, p = 0.36...Continue Reading

References

Jun 1, 1981·Circulation·H R SchelbertD E Kuhl
Jun 23, 1994·The New England Journal of Medicine·N G UrenP G Camici
Feb 1, 1994·Journal of the American College of Cardiology·S N WeindlingS T Treves
Jan 1, 1997·Journal of the American College of Cardiology·P BonhoefferD Sidi
Oct 6, 1997·The Annals of Thoracic Surgery·K YatsunamiY Imai
Feb 13, 2001·European Heart Journal·M Giulia GagliardiP Ragonese
Jun 28, 2001·The Annals of Thoracic Surgery·J W BrownM W Turrentine

❮ Previous
Next ❯

Citations

Apr 13, 2011·Current Cardiology Reports·Susan Lucy RocheErwin Notker Oechslin
Nov 30, 2010·Pediatric Clinics of North America·Masato Takahashi
Aug 14, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Belma Saygili KaragolSelmin Karademir

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.