Coronary dilatation reserve in experimental hypertension and chronic heart failure: effects of blockade of the renin-angiotensin system

Clinical and Experimental Pharmacology & Physiology
C RicherJ-F Giudicelli

Abstract

1. The aim of the present study was to investigate left and right ventricular (LV and RV, respectively) coronary vasodilatation reserve (CVR; fluorescent microsphere technique) in rats with hypertension (spontaneously hypertensive rats (SHR)) or congestive heart failure (CHF) and the effects of early and chronic renin-angiotensin system (RAS) blockade thereupon. 2. In adult SHR, both LV and RV CVR were impaired, especially in the non-hypertrophied RV, the main factor involved being coronary vascular remodelling. Blockade of the RAS normalized both LV and RV CVR, mainly through the prevention of hypertension and suppression of the resulting pericoronary fibrosis. 3. In postischaemic CHF rats, there was an early and severe degradation of LV and RV CVR that developed before any significant vascular remodelling and appeared to be linked to the deterioration of cardiac hypertrophy and haemodynamics. This degradation in CVR further worsened over the longer term due to late-developing pericoronary fibrosis and endothelial dysfunction. Blockade of the RAS had no early effects on LV and RV CVR, but improved RV CVR over the long term, mainly by limiting RV hypertrophy and by preventing the development of pericoronary fibrosis and coronar...Continue Reading

References

Mar 1, 1990·Journal of the American College of Cardiology·R J Tomanek
Aug 1, 1995·European Heart Journal·J B MichelJ F Arnal
Mar 9, 1999·Journal of Cardiovascular Pharmacology·M GervaisJ F Giudicelli
Sep 7, 2000·Journal of Cardiovascular Pharmacology·C RicherJ F Giudicelli
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·P MenetonF Alhenc-Gelas

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Citations

Jul 17, 2008·Vascular Health and Risk Management·Roberto Negro
Aug 2, 2005·European Journal of Pharmacology·Pedro MonteiroLuís A Providência
May 25, 2004·Nuclear Medicine Communications·Gulay Durmus AltunSakir Berkarda
May 23, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jorge SuarezWolfgang H Dillmann

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