Coronary endothelial dysfunction and myocardial cell damage in chronic stable idiopathic dilated cardiomyopathy

International Journal of Cardiology
V MartíJosep M Augé

Abstract

Impairment of endothelium-dependent vasodilatation in response to acetylcholine reflects an abnormal endothelial function. Labelled indium-111 monoclonal antimyosin antibodies enable detection of myocardial cell damage. We analysed whether endothelial dysfunction correlates with myocardial antimyosin uptake in a selected group of patients with idiopathic dilated cardiomyopathy. Twenty-two consecutive patients with chronic stable idiopathic dilated cardiomyopathy (18 males and four females) were included. The duration of heart failure symptoms was 46+/-34 months. At inclusion, the functional class of New York Heart Association was 2.1+/-0.7. Endothelial function was evaluated using intracoronary graded concentrations of acetylcholine. Vasomotor responses of the left anterior descending coronary artery were measured by quantitative coronary analysis. Myocardial uptake of antimyosin antibodies was quantified by means of a heart-to-lung ratio (HLR). Eighteen patients showed endothelial dysfunction (82%) and the remaining four patients showed a normal endothelial function. There were no statistically significant differences between patients with and without endothelial dysfunction in relation to clinical, echocardiographic and hemod...Continue Reading

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Citations

Mar 15, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Albert Flotats, Ignasi Carrió
Jan 30, 2016·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Takashi Hitsumoto
Feb 27, 2004·European Journal of Clinical Investigation·A Y ChongG Y H Lip
Feb 15, 2005·International Journal of Cardiology·Emiyo OgawaTakeshi Nakano
Mar 10, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Frank Lloyd DiniSalvatore Mario De Tommasi
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yukitaka Shizukuda, Peter M Buttrick

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