Coronary flow reserve and heart failure in experimental coxsackievirus myocarditis. A transthoracic Doppler echocardiography study

American Journal of Physiology. Heart and Circulatory Physiology
Antti SarastePekka Saukko

Abstract

The objective of this study was to apply transthoracic Doppler echocardiography (TTDE) in mice to study coronary flow reserve (CFR), an index of coronary microvascular function, in mild and severe forms of experimental viral myocarditis. Regarding methodology, BALB/c mice were infected with cardiotropic coxsackieviruses causing either a mild (Nancy strain) or a severe (Woodruff strain) myocarditis. Left ventricular dimensions, fractional shortening, and CFR (ratio of left coronary artery flow velocity during maximal adenosine-induced vasodilatation to rest) were measured by TTDE before infection and again 1 or 2 wk after infection. As a result, the resting flow velocity did not change after infection. In contrast, CFR reduced significantly 1 wk after infection with either virus variant [from 2.5 (SD 0.3) to 1.4 (SD 0.1) in severe and from 2.4 (SD 0.4) to 2.1 (SD 0.3) in mild myocarditis], being significantly lower in the severe than mild myocarditis. CFR remained low in severe myocarditis 2 wk after infection. Fractional shortening decreased to the same levels 1 wk after infection with either virus variant [from 0.54 (SD 0.02) to 0.43 (SD 0.03) in severe and from 0.51 (SD 0.03) to 0.44 (SD 0.02) in mild myocarditis, P < 0.05]. ...Continue Reading

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Citations

Jul 24, 2013·Journal of Cardiovascular Translational Research·Li-Ming GanRegina Fritsche-Danielson
May 17, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Craig J HartleyGeorge E Taffet
Aug 30, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Rashmi RamBurns C Blaxall
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Jan 23, 2016·Ultrasound in Medicine & Biology·Francesca LenzariniFrancesco Faita
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Aug 24, 2010·Journal of Cardiovascular Pharmacology·Jian GuanGuoGan Wang
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Mar 27, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Hélène ThibaultGeneviève Derumeaux
Oct 23, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Sauli UotilaAntti Saraste
Sep 25, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Jieyun YouYunzeng Zou
Jan 14, 2022·European Journal of Nuclear Medicine and Molecular Imaging·Ahmed HaiderCatherine Gebhard

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