Coronary flow reserve is impaired in patients with slow coronary flow

Atherosclerosis
Dogan ErdoganHaldun Muderrisoglu

Abstract

Slow coronary flow (SCF) in a normal coronary angiogram is a well-recognized clinical entity, but its etiopathogenesis remains unclear. However, previous studies have suggested that microvascular abnormalities and endothelial dysfunction responsible for SCF. Accordingly, we hypothesized that SCF phenomenon may be a form, at least early phase, of atherosclerosis that involve both small vessels and epicardial coronary arteries, and therefore we investigated coronary flow reserve (CFR) reflecting coronary microvascular function in patients with SCF. Twenty subjects with SCF and 15 control subjects with normal coronary flow were studied. Coronary flow was quantified according to TIMI frame count (TFC). Coronary diastolic peak flow velocities were measured at baseline and after dipyridamole infusion. CFR was calculated as the ratio of hyperemic to baseline diastolic peak velocities. Demographic features, coronary risk factors, echocardiographic measurements except diastolic function parameters, and biochemical measurements were similar between the groups. CFR values were significantly lower in subjects with SCF than in the control group (1.99+/-0.38 versus 2.99+/-0.47, P<0.0001). In addition, TIMI frame count independently correlate...Continue Reading

References

Feb 1, 1991·Journal of the American College of Cardiology·A MaseriT Crake
May 1, 1968·Circulation Research·W M Fam, M McGregor
Jul 30, 2002·Cardiology·John F BeltrameJohn D Horowitz
Sep 17, 2003·Cardiology·Luiz A Machado Cesar
Jan 9, 2004·Japanese Heart Journal·V Gökhan CinOben Döven
Jul 6, 2004·Journal of the American College of Cardiology·John F BeltrameJohn D Horowitz
Oct 14, 2004·Journal of Hypertension·Maurizio GalderisiGiovanni de Simone
Apr 30, 2005·International Heart Journal·Mustafa YaziciErdogan Yasar
Jan 18, 2006·Medical Hypotheses·Jian-Jun LiXue-Wen Qin

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Citations

Jan 24, 2009·Heart and Vessels·Hatice SelcukAli Sasmaz
May 31, 2012·Cardiology Research and Practice·Muhammad A ChaudhryRalph Lazzara
Feb 16, 2008·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Guenter PilzPeter Bernhardt
Aug 13, 2011·The Tohoku Journal of Experimental Medicine·Osman KarakayaIrfan Barutcu
Dec 3, 2014·Ultrasound in Medicine & Biology·Song YangBu-Xing Chen
Nov 16, 2007·Coronary Artery Disease·Ali YildizOzcan Erel
Jul 16, 2008·The International Journal of Cardiovascular Imaging·Zekeriya NurkalemMehmet Eren
Oct 31, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bozena SobkowiczWlodzimierz J Musial
Aug 29, 2012·Medical Hypotheses·Qixia JiangChun Liang
Apr 14, 2010·Medical Hypotheses·Xiao WangShao-Ping Nie
Jun 1, 2007·Atherosclerosis·Ali YildizOzcan Erel
Feb 11, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Muhsin TürkmenIrfan Barutcu
Mar 6, 2015·Echocardiography·Ahmet BarutçuBurak Altun
Feb 19, 2016·Scandinavian Cardiovascular Journal : SCJ·Harun KundiFeridun Vasfi Ulusoy
Dec 2, 2014·International Journal of Cardiology·Dilek YalvacErtan Yetkin
May 1, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Serpil ErogluHaldun Muderrisoglu
Jul 4, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ugur CanpolatSinan Aydogdu
Nov 27, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Harun KundiFeridun Vasfi Ulusoy
Jun 9, 2010·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Kenji SadamatsuHaruki Tanaka
May 31, 2019·International Heart Journal·Koki Nakanishi, Masao Daimon
Mar 30, 2021·Angiology·George Chalikias, Dimitrios Tziakas

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