Coronary flow velocity changes after intravenous dipyridamole infusion: measurements using intravascular Doppler guide wire. A documentation of flow inhomogeneity

Journal of the American College of Cardiology
V VoudrisD V Cokkinos

Abstract

This study assessed changes in coronary flow velocity measured distal to a significant stenosis of the left anterior descending coronary artery and at the adjacent normal left circumflex coronary artery, produced by intravenous administration of dipyridamole, in patients undergoing coronary angioplasty with a documented perfusion defect on dipyridamole-thallium-201 scintigraphy. Significant flow inhomogeneity is believed to develop during coronary vasodilation induced by dipyridamole, causing a defect in the thallium-201 scintigram. The recently developed intracoronary Doppler guide wire permits assessment of flow velocity variables in normal and stenotic arteries. In 17 patients with stable angina we studied changes in time-averaged peak velocity and the diastolic/systolic velocity ratio simultaneously using two 0.014-in. (0.36-mm) Doppler guide wires at baseline and after 4 min of dipyridamole infusion (0.56 mg/kg body weight). Coronary flow velocity reserve and relative flow reserve were correlated with the degree of stenosis on coronary angiography and quantitative analysis of thallium-201 images. No changes in distal flow velocity was observed in the stenotic vessel (5.5 +/- 33.7% [mean +/- SD]), in contrast to a significa...Continue Reading

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Citations

Jun 19, 1997·The American Journal of Cardiology·A E Iskandrian, J Heo
Jun 29, 1999·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·H TeragawaG Kajiyama
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Mar 18, 2003·Heart·D V CokkinosV Voudris
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Feb 26, 2019·The International Journal of Cardiovascular Imaging·Takatoshi HigashikawaHajime Sakuma

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